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논문 기본 정보

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학술저널
저자정보
Hur, Hyuk (Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Medical School and Hwasun Hospital) Ryu, Hyang-Hwa (Brain Tumor Clinic and Gamma Knife Center, Brain Tumor Research Laboratory, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Medical Schoo) Li, Chun-Hao (Brain Tumor Clinic and Gamma Knife Center, Brain Tumor Research Laboratory, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Medical School) Kim, In Young (Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Medical School and Hwasun Hospital) Jang, Woo-Youl (Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Medical School and Hwasun Hospital) Jung, Shin (Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Cho)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제59권 제6호
발행연도
2016.1
수록면
551 - 558 (8page)

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Malignant glioma cells invading surrounding normal brain are inoperable and resistant to radio- and chemotherapy, and eventually lead to tumor regrowth. Identification of genes related to motility is important for understanding the molecular biological behavior of invasive gliomas. According to our previous studies, Metallothionein 1E (MT1E) was identified to enhance migration of human malignant glioma cells. The purpose of this study was to confirm that MT1E could modulate glioma invasion in vivo. Firstly we established 2 cell lines; MTS23, overexpressed by MT1E complementary DNA construct and pV12 as control. The expression of matrix metalloproteinases (MMP)-2, -9 and a disintegrin and metalloproteinase 17 were increased in MTS23 compared with pV12. Furthermore it was confirmed that MT1E could modulate MMPs secretion and translocation of NFkB p50 and B-cell lymphoma-3 through small interfering ribonucleic acid knocked U87MG cells. Then MTS23 and pV12 were injected into intracranial region of 5 week old male nude mouse. After 4 weeks, for brain tissues of these two groups, histological analysis, and immunohistochemical stain of MMP-2, 9 and Nestin were performed. As results, the group injected with MTS23 showed irregular margin and tumor cells infiltrating the surrounding normal brain, while that of pV12 (control) had round and clear margin. And regrowth of tumor cells in MTS23 group was observed in another site apart from tumor cell inoculation. MT1E could enhance tumor proliferation and invasion of malignant glioma through regulation of activation and expression of MMPs.
#Metallothionein 1E #Malignant glioma #Invasion #Brain tumor model #MMP-2 #MMP-9

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참고문헌 (26)

참고문헌 신청
Agrawal A / 2008 / Zinc-binding groups modulate selective inhibition of MMPs / ChemMed- Chem 3:812~820 google schola Andela VB / 2003 / NFkappaB : a pivotal transcription factor in prostate cancer metastasis to bone / Clin Orthop Relat Res 415(Suppl):S75~S85 google schola Arriaga JM / 2012 / Metallothionein expression in colorectal cancer : relevance of different isoforms for tumor progression and patient survival / Hum Pathol 43:197~208 google schola Chen X / 2013 / ADAM17 promotes U87 glioblastoma stem cell migration and invasion / Brain Res 1538:151~158 google schola Escárcega RO / 2007 / The transcription factor nuclear factor-kappa B and cancer / Clin Oncol (R Coll Radiol) 19:154~161 google schola

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