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학술저널
저자정보
Kim, Suzy (Department of Radiation Oncology, Seoul National University Boramae Medical Center) Oh, Sowon (Department of Nuclear Medicine, Seoul National University Boramae Medical Center) Kim, Jin Soo (Department of Internal Medicine, Seoul National University Boramae Medical Center) Kim, Yu Kyeong (Department of Nuclear Medicine, Seoul National University Boramae Medical Center) Kim, Kwang Hyun (Department of Otolaryngology, Seoul National University Boramae Medical Center) Oh, Do Hoon (Department of Radiation Oncology, Chung-Ang University Hostpial) Lee, Dong-Han (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital) Jeong, Woo-Jin (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital) Jung, Young Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital)
저널정보
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제36권 제2호
발행연도
2018.1
수록면
95 - 102 (8page)

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Purpose: To evaluate the prognostic value of $^{18}F$-fluorodeoxyglucose positron-emission tomography (FDG PET) with computed tomography (CT) before and during radiotherapy (RT) in patients with head and neck cancer. Methods: Twenty patients with primary head and neck squamous cell carcinoma were enrolled in this study, of whom 6 had oropharyngeal cancer, 10 had hypopharyngeal cancer, and 4 had laryngeal cancer. Fifteen patients received concurrent cisplatin and 2 received concurrent cetuximab chemotherapy. FDG PET/CT was performed before RT and in the 4th week of RT. The parameters of maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor were measured, and the prognostic significance of each was analyzed with the Cox proportional hazards model. Results: Higher TLG (>19.0) on FDG PET/CT during RT was a poor prognostic factor for overall survival (OS) (p = 0.001) and progression-free survival (PFS) (p = 0.007). In the multivariate analysis, TLG during RT as a continuous variable was significantly associated with OS and PFS rate (p = 0.023 and p = 0.016, respectively). Tumor response worse than partial remission at 1 month after RT was another independent prognostic factor for PFS (p = 0.024). Conclusions: Higher TLG of the primary tumor on FDG PET/CT during RT was a poor prognostic factor for OS and PFS in patients with head and neck cancer.

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