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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 11 (11page)
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Objective: To investigate the prognostic value of metabolic tumor volume (MTV) and totallesion glycolysis (TLG), measured by preoperative 18F-fluorodeoxyglucose positron emissiontomography/computed tomography (18F-FDG PET/CT), in risk stratification of patients withendometrial carcinoma (EC). Methods: The patients with pathological diagnosis of EC who underwent preoperative18F-FDG PET/CT imaging were retrospectively selected for analysis of the prognostic valuesof PET parameters in risk classification and lymph node metastases (LNMs). Receiveroperating-characteristic analysis was used to analyze the correlation of PET parameters cutoffvalues with deep myometrial invasion (MI), lymphovascular space involvement and LNM forprognostic values in risk stratification. Results: The sensitivity, specificity, positive predictive value, negative predictive value andaccuracy for detection of LNM are 83.3%, 99.7%, 90.9%, 99.5% and 99.2%, respectively. TheMTV and TLG of primary lesion of EC in the patients with LNM are notably higher than thosein patients without LNM, p<0.010. The MTV and TLG of the EC primary lesions in high-riskpatients are significantly higher than those in low-risk patients (p<0.010), but the maximumstandardized uptake value (SUVmax) is not. The MTV and TLG of primary lesions weresuperior to SUVmax for predicting of deep MI, LNM and high-risk of EC (p<0.005). Conclusion: MTV and TLG of primary lesions are more valuable in predicting riskstratification of EC patients. Preoperative 18F-FDG PET/CT imaging is useful in predictingthe LNM of EC and may help guide pelvic lymphadenectomy to avoid unnecessary pelviclymphadenectomy in EC patients with low-risk stratification.
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참고문헌 (29)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
Tirumani SH / 2013 / Current concepts in the diagnosis and management of endometrial and cervical carcinomas / Radiol Clin North Am 51:1087~1110
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Boyraz G / 2017 / Incidence of lymph node metastasis in surgically staged FIGO Ia G1/G2 endometrial cancer with a tumor size of more than 2 cm / Int J Gynecol Cancer 27:486~492
Kitajima K / 2015 / Preoperative risk stratification using metabolic parameters of 18F-FDG PET/CT in patients with endometrial cancer / Eur J Nucl Med Mol Imaging 42:1268~1275
Tirumani SH / 2013 / Current concepts in the diagnosis and management of endometrial and cervical carcinomas / Radiol Clin North Am 51:1087~1110
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Boyraz G / 2017 / Incidence of lymph node metastasis in surgically staged FIGO Ia G1/G2 endometrial cancer with a tumor size of more than 2 cm / Int J Gynecol Cancer 27:486~492
Kitajima K / 2015 / Preoperative risk stratification using metabolic parameters of 18F-FDG PET/CT in patients with endometrial cancer / Eur J Nucl Med Mol Imaging 42:1268~1275
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