Cytogenetic Profile of De Novo B lineage Acute Lymphoblastic Leukemia: Determination of Frequency, Distribution Pattern and Identification of Rare and Novel Chromosomal Aberrations in Indian Patients

Bhandari, Prerana; Ahmad, Firoz; Dalvi, Rupa; Koppaka, Neeraja; Kokate, Prajakta; Das, Bibhu Ranjan; Mandava, Swarna

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저자정보: Bhandari, Prerana (Research and Development, SRL Ltd.) Ahmad, Firoz (Research and Development, SRL Ltd.) Dalvi, Rupa (Cytogenetic Division, SRL Ltd.) Koppaka, Neeraja (Cytogenetic Division, SRL Ltd.) Kokate, Prajakta (Cytogenetic Division, SRL Ltd.) Das, Bibhu Ranjan (Research and Development, SRL Ltd.) Mandava, Swarna (Cytogenetic Division, SRL Ltd.)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제16호

발행연도: 2015.1

수록면: 7,219 - 7,229 (11page)

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Background: Chromosomal aberrations identified in acute lymphoblastic leukemia (ALL) have an important role in disease diagnosis, prognosis and management. Information on karyotype and associated clinical parameters are essential to physicians for planning cancer control interventions in different geographical regions. Materials and Methods: In this study, we present the overall frequency and distribution patterns of chromosomal aberrations in both children and adult de novo B lineage ALL Indian patients using conventional cytogenetics, interphase FISH and multiplex RT-PCR. Results: Among the 215 subjects, cytogenetic results were achieved in 172 (80%) patients; normal karyotype represented 37.2% and abnormal 62.8% with a distribution as follows: 15.3% hypodiploidy; 10.3% hyperdiploidy; 15.8% t(9;22); 9.8% t(1;19); 3.7% t(12;21); 2.8% t(4;11); 2.8% complex karyotypes. Apart from these, we observed several novel, rare and common chromosomal rearrangements. Also, FISH studies using LSI extra-signal dual-color probes revealed additional structural or numerical changes. Conclusions: These results demonstrate cytogenetic heterogeneity of ALL and confirm that the incidence of chromosomal abnormalities varies considerably. To the best of our knowledge, this is one of the largest reported series of cytogenetic investigations in Indian B-lineage ALL cases. In addition, ongoing cytogenetic studies are warranted in larger groups of B-lineage ALL cases to identify newly acquired chromosomal abnormalities that may contribute to disease diagnosis and management.

#Acute lymphoblastic leukemia #cytogenetic analysis #fluorescence in situ hybridization

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