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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 446 - 453 (8page)
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Purpose ETV6/RUNX1 (+) acute lymphoblastic leukemia (ALL), which is the most common genetic subtype of pediatric ALL, has a favorable prognosis. In this study, we analyzed the outcome of ETV6/RUNX1 (+) ALL patients treated at our institution with the aim of identifying significant prognostic variables.
Materials and Methods Sixty-three patients were diagnosed with ETV6/RUNX1 (+) ALL from 2005 to 2011. Prognostic variables studied included minimal residual disease (MRD) as detected by ETV6/RUNX1 (+) fusion, and the presence of additional cytogenetic abnormalities.
Results The 5-year event-free survival was 84.1±4.6%, with 10 patients relapsing at a median of 28.3 months from diagnosis for a 5-year cumulative incidence of relapse of 15.9±4.6%.
Multivariate analysis revealed that the presence MRD, as detected by real-time quantitative- polymerase chain reaction or fluorescence in situ hybridization for ETV6/RUNX1 fusion at end of remission induction, and the presence of additional structural abnormalities of 12p (translocations or inversions) negatively affected outcome. Despite treatment such as allogeneic hematopoietic cell transplantation, eight of the 10 relapsed patients died from disease progression for overall survival of 82.5±6.9%.
Conclusion ETV6/RUNX1 (+) ALL may be heterogeneous in terms of prognosis, and variables such as MRD at end of remission induction or additional structural abnormalities of 12p could define a subset of patients who are likely to have poor outcome.
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참고문헌 (22)
참고문헌 신청
Gandemer V / 2012 / Excellent prognosis of late relapses of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia : lessons from the FRALLE 93 protocol / Haematologica 97:1743~1750
Drunat S / 2001 / Quantification of TEL-AML1 transcript for minimal residual disease assessment in childhood acute lymphoblastic leukaemia / Br J Haematol 114:281~289
de Haas V / 2002 / The TEL-AML1 real-time quantitative polymerase chain reaction(PCR)might replace the antigen receptor-based genomic PCR in clinical minimal residual disease studies in children with acute lymphoblastic leukaemia / Br J Haematol 116:87~93
Amare Kadam PS / 2008 / Coexistence of ETV6/RUNX1 and MLL aberrations in B-cell precursor acute lymphoblastic leukemia discloses a small subclass of BCP-ALL / Cancer Genet C
Attarbaschi A / 2004 / Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia : an interphase FISH analysis / Leuke
Drunat S / 2001 / Quantification of TEL-AML1 transcript for minimal residual disease assessment in childhood acute lymphoblastic leukaemia / Br J Haematol 114:281~289
de Haas V / 2002 / The TEL-AML1 real-time quantitative polymerase chain reaction(PCR)might replace the antigen receptor-based genomic PCR in clinical minimal residual disease studies in children with acute lymphoblastic leukaemia / Br J Haematol 116:87~93
Amare Kadam PS / 2008 / Coexistence of ETV6/RUNX1 and MLL aberrations in B-cell precursor acute lymphoblastic leukemia discloses a small subclass of BCP-ALL / Cancer Genet C
Attarbaschi A / 2004 / Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia : an interphase FISH analysis / Leuke
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