메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Shargh, Shohreh Alizadeh (Department of Medical Laboratory Science, Midwifery-Nursing Institute, Islamic Azad University of Chalous Branch) Movafagh, Abolfazl (Department of Medical Genetics, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences) Zarghami, Nosratolah (Department of medical Biotechnology, Tabriz University of Medical Sciences) Sayad, Arezou (Department of Medical Genetics, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences) Mansouri, Neda (Department of Medical Genetics, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences) Taheri, Mohammad (Department of Medical Genetics, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences) Pour, Atefeh Heidary (Department of Cell and Molecular Biology, Pharmaceutical Sciences Branch, Islamic Azad University) Iranpour, Mostafa (Department of Medical Genetics, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences) Ghaedi, Hamid (Department of Medical Genetics, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences) Montazeri, Vahid Massoudi, Nilofar Hashemi, Mehrdad Mortazavi-Tabatabaei, SA
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제3호
발행연도
2016.1
수록면
179 - 183 (5page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Breast cancer is the most prevalent type of cancer among women around the world, and mortality is primarily caused by micro-metastatic disease. The complex mechanisms of breast cancer invasion and metastasis are intrinsically related to the malignant cell type so that early detection of micro-metastases can help prolongation of survival for patient. The aim of the present research work was evaluation of the expression status of mammoglobin protein as a candidate molecular marker in the negative sentinel lymph node (SLN). Fifty tumor specimens, and 50 normal adjacent breast tissue samples from the same patients were selected on the basis of having more than 10% tumor content for RNA extraction from SLNs. Tumor samples and normal adjacent breast tissue were archived in the form of frozen fresh tissue in liquid nitrogen. Real-time PCR was performed on a Bioner life express gradient thermal cycler system. Mammoglobin gene overexpression in breast cancer metastasis was investigated. Single marker results were mammaglobin 66.7% and CK19 50.0%, with 58.3% for the two in combination. Due to improved outcome with at least 3 genes (83.3%), it seems, triple marker evaluation will be most likely useful for detecting micro-metastases instead of studying separate genes.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0