Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women - Results from the Japan Collaborative Cohort (JACC) Study

Nitta, Junichi; Nojima, Masanori; Ohnishi, Hirofumi; Mori, Mitsuru; Wakai, Kenji; Suzuki, Sadao; Fujino, Yoshihisa; Lin, Yingsong; Tamakoshi, Koji; Tamakoshi, Akiko

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자료유형: 학술저널

저자정보: Nitta, Junichi (Department of Public Health, School of Medicine, Sapporo Medical University) Nojima, Masanori (Center for Translational Research, The Institute of Medical Science Hospital, the University of Tokyo) Ohnishi, Hirofumi (Department of Public Health, School of Medicine, Sapporo Medical University) Mori, Mitsuru (Department of Public Health, School of Medicine, Sapporo Medical University) Wakai, Kenji (Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine) Suzuki, Sadao (Department of Public Health, Nagoya City University Graduate School of Medical Science) Fujino, Yoshihisa (Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health) Lin, Yingsong (Department of Public Health, Aichi Medical University School of Medicine) Tamakoshi, Koji (Department of Nursing, Nagoya University Graduate School of Medicine) Tamakoshi, Akiko (Department of Public Health, Hokkaido University Graduate School of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제3호

발행연도: 2016.1

수록면: 1,437 - 1,443 (7page)

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Background: We investigated four factors, height, weight gain since age 20, physical activity, and alcohol drinking, for associations with risk of breast cancer (BC) according to menopausal status, using the latest data of the Japan Collaborative Cohort Study (JACC Study). Materials and Methods: We confined the analysis to 24 areas available of cancer incidence information, excluding women with a previous diagnosis of BC. Baseline data were collected from 38,610 (9,367 premenopausal, and 29,243 postmenopausal) women during 1988 and 1990. The study subjects were followed-up at the end of 2009, and 273 (84 premenopausal, and 189 postmenopausal) cases of BC were newly diagnosed in 501,907 person-years. The Cox model was used to estimate a hazards ratio (HR) and its 95% confidence interval (CI) of BC risk. Results: As a result of the multivariate analysis adjusting for age at baseline survey, age at menarche, number of live births, and, age at first delivery, weight gain since age 20 of 6.7 kg-9.9 kg, and ${\geq}10.0kg$ were significantly associated with increased risk for postmenopausal BC (HR=2.48, 95% CI 1.40-4.41, and, HR=2.94, 95% CI 1.84-4.70, respectively). Significantly increased trend of BC risk was also observed in weight gain since age 20 (p for trend, p<0.001). Amount of ethanol intake per day${\geq}15.0g$ was significantly associated with increased risk for postmenopausal BC in the multivariable-adjusted analysis (HR=2.74, 95% CI 1.32-5.70). Conclusions: Higher weight gain in adulthood and larger amounts of ethanol intake were significantly associated with increased risk of BC in Japanese postmenopausal women. None of the investigated factors were significantly associated with BC risk in Japanese premenopausal women.

#Breast cancer #cohort study #menopausal status #weight gain #alcohol drinking

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