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자료유형
학술저널
저자정보
Shamsabadi, Fatemeh T (Faculty of Medicine, Semnan University of Medical Sciences) Eidgahi, Mohammad Reza Akbari (Semnan Biotechnology Research Center, Semnan University of Medical Sciences) Mehrbod, Parvaneh (Influenza research lab, Virology Department, Pasture Institute) Daneshvar, Nasibeh (Biological Sciences Building, University of Manitoba) Allaudin, Zeenathul Nazariah (Faculty of Veterinary Medicine, Universiti Putra Malaysia) Yamchi, Ahad (Gorgan University of Agricultural Sciences and Natural Resources) Shahbazi, Majid (Golestan University of Medical Sciences)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제8호
발행연도
2016.1
수록면
3,711 - 3,719 (9page)

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Drawbacks of conventional cancer treatments, with lack of specificity and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor-specific promoter action. The search engine and databases utilized were Science direct, PubMed, MEDLINE and Google. In addition to cell-cycle modulation, apoptosis inhibition, interaction in cell-signaling pathways, cancer-selective expression, survivin also may be considered as specific target through its promoter as a novel treatment for cancer. Our purpose in writing this article was to create awareness in researchers, emphasizing relation of survivin gene expression to potential cancer treatment. The principal result and major conclusion of this manuscript are that survivin structure, biological functions and applications of RNA interference systems as well as tumor-specific promoter activity are of major interest for cancer gene therapy.

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