Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

Okuturlar, Yildiz; Gunaldi, Meral; Tiken, Elif Eda; Oztosun, Bugra; Inan, Yesim Ozdem; Ercan, Tarik; Tuna, Savas; Kaya, Ali Osman; Harmankaya, Ozlem; Kumbasar, Abdulbaki

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자료유형: 학술저널

저자정보: Okuturlar, Yildiz (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Gunaldi, Meral (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Tiken, Elif Eda (Radiation Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Oztosun, Bugra (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Inan, Yesim Ozdem (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Ercan, Tarik (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Tuna, Savas (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Kaya, Ali Osman (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Harmankaya, Ozlem (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) Kumbasar, Abdulbaki (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제6호

발행연도: 2015.1

수록면: 2,409 - 2,412 (4page)

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Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.

#Breast cancer #complete blood count #neutrophils #platelet distribution width

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