Application of Joint Detection of AFP, CA19-9, CA125 and CEA in Identification and Diagnosis of Cholangiocarcinoma

Li, Yong; Li, Da-Jiang; Chen, Jian; Liu, Wei; Li, Jian-Wei; Jiang, Peng; Zhao, Xin; Guo, Fei; Li, Xiao-Wu; Wang, Shu-Guang

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자료유형: 학술저널

저자정보: Li, Yong (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Li, Da-Jiang (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Chen, Jian (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Liu, Wei (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Li, Jian-Wei (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Jiang, Peng (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Zhao, Xin (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Guo, Fei (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Li, Xiao-Wu (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University) Wang, Shu-Guang (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제8호

발행연도: 2015.1

수록면: 3,451 - 3,455 (5page)

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Objective: To explore the application of joint detection of serum AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma (CC). Materials and Methods: The levels of serum AFP, CA19-9, CA125 and CEA of both 30 patients with CC and 30 patients with hepatocellular carcinoma (HCC) were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic effects of single and joint detection of those 4 kinds of tumor markers for CC. Results: The levels of serum CA19-9, CA125 and CEA in CC patients were higher than that in HCC patients,whereas that of serum AFP was significantly lower s. The area under ROC curve of single detection of serum AFP, CA19-9, CA125 and CEA were 0.05, 0.86, 0.84 and 0.83, with the optimal cutoff values of 15.4 ng/ml, 125.1 U/ml, 95.7 U/ml and 25.9 ng/ml, correspondingly, and the percentage correct single diagnosis was <79%. With joint detection, the diagnostic effect of combined AFP, CA19-9, CA125 and CEA was the highest, with an area under the ROC curve of 0.94 (95%CI 0.88~0.99). Conclusions: Single detection of serum CA19-9, CA125 and EA is not meaningful. The sensitivity, specificity, the rate of correct diagnosis and the area under ROC curve of joint detection of AFP, CA19-9, CA125 and CEA are highest, indicating that the joint detection of these 4 tumor markers is of great importance in the diagnosis of CC.

#Cholangiocarcinoma #hepatocellular carcinoma #tumor markers #identification and diagnosis #ROC curve

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