Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features

김나리; 박원; 조원경; 배덕수; 김병기; 이정원; 최철훈; 김태중; 이유영

doi:https://doi.org/10.3802/jgo.2021.32.e72

Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features

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Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features

자료유형: 학술저널

저자정보: 김나리 (성균관의대) 박원 (삼성서울병원) 조원경 (삼성서울병원) 배덕수 (삼성서울병원) 김병기 (성균관대학교) 이정원 (삼성서울병원) 최철훈 (삼성서울병원) 김태중 (삼성서울병원) 이유영 (성균관대학교 의과대학)

저널정보: 대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.32 No.5 KCI등재

발행연도: 2021.9

수록면: 1 - 11 (11page)

DOI: https://doi.org/10.3802/jgo.2021.32.e72

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Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features

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Objective: Unlike cervical squamous cell carcinoma, there are no consensus criteria for serum tumor markers in cervical adenocarcinoma. This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels in cervical adenocarcinoma patients with adverse pathologic features. Methods: A total of 105 patients who underwent radical hysterectomy followed by adjuvant radiotherapy (RT) or concurrent chemoradiation therapy were included. Locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were evaluated using the Cox proportional hazard regression model. Results: Using a cutoff value of 50 U/mL, 83 and 22 patients had low- and high-CA125, respectively. Patients with high-CA125 had a larger tumor size, more frequent parametrial extension, and more frequent lymph node metastasis than those with low-CA125. During a median follow-up of 59.3 (interquartile range, 32.7?97.8) months, patients with high-CA125 showed inferior 5-year LRFS, DMFS, and OS rates compared to those with low-CA125 (38.5% vs. 70.0%; 37.0% vs. 69.4%; 43.6% vs. 78.1%, respectively, all p<0.05). In multivariable analysis, the high-CA125 remained significant prognostic factor for LRFS, DMFS, and OS (all p<0.05). Furthermore, 12 patients with high-CA125 at recurrence exhibited lower 5-year OS rates than 21 patients with low-CA125 at recurrence (0.0% vs. 51.3%, p=0.003). Conclusion: In this retrospective analysis, the serum CA125 level at diagnosis and recurrence was related to the extent of disease and prognosis of cervical adenocarcinoma with adverse pathologic features. A CA125 level of ≥50 U/mL may be a prognostic surrogate marker for cervical adenocarcinoma in patients with the presence of adverse factors.

#Cervical Cancer #Adenocarcinoma #Carbohydrate Antigen 125 #Radiotherapy #Prognosis

참고문헌 (28)

참고문헌 신청

Chung HH / 2006 / Cervical cancer incidence and survival in Korea: 1993–2002 / Int J Gynecol Cancer 16:1833~1838

Chan PG / 2003 / Changes in cervical cancer incidence after three decades of screening US women less than 30 years old / Obstet Gynecol 102:765~773

Galic V / 2012 / Prognostic significance of adenocarcinoma histology in women with cervical cancer / Gynecol Oncol 125:287~291

양경미 / 2017 / Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer / Radiation oncology journal 35(1):39~47

백이선 / 2020 / Prognostic Model for Survival and Recurrence in Patients with Early-Stage Cervical Cancer: A Korean Gynecologic Oncology Group Study (KGOG 1028) / Cancer Research and Treatment 52(1):320~333

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김나리

소속기관 연세대학교

주요연구분야 사회과학 > 행정학 공학 > 컴퓨터학

논문수 25 이용수 2,743

박원

소속기관 삼성서울병원

주요연구분야 의약학 > 임상의학 > 산부인과학

논문수 11 이용수 3

조원경

소속기관 삼성서울병원

주요연구분야 의약학 > 임상의학 > 산부인과학

논문수 3 이용수 1

배덕수

소속기관 삼성서울병원