지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 128 - 135 (8page)
이용수
초록· 키워드
오류제보하기
5-hydroxytryptamine (serotonin) receptor ($5-HT_7R$) 7 is one of G-Protein coupled receptors, which is activated by the neurotransmitter Serotonin. After activation by serotonin, $5-HT_7$ activates the production of the intracellular signaling molecule cyclic AMP. $5-HT_7$ receptor has been found to be involved in the pathophysiology of various disorders. It is reported that $5-HT_7$ receptor antagonists can be used as antidepressant agents. In this study, we report the important structural and chemical parameters for 2-methoxyphenylpiperazinylakanamides as $5-HT_7R$ inhibitors. A 3D QSAR study based on comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with $q^2$ of 0.594 with 6 components, $r^2$ of 0.986, Fisher value as 60.607, and an estimated standard error of 0.043. The predictive ability of the test set was 0.602. Results obtained the CoMFA models suggest that the data are well fitted and have high predictive ability. The contour maps are generated and studied. The contour analyses may serve as tool in the future for designing of novel and more potent $5-HT_7R$ derivatives.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
3D-QSAR Studies of 8-Substituted-2-aryl-5-alkylaminoquinolines as Corticotropin-releasing Factor-1 Receptor Antagonists
조선자연과학논문집
2015 .01
-
3D Structure Prediction of Human 5-Hydroxytryptamine Receptor 7 (5-HT<sub>7</sub>R)
조선자연과학논문집
2018 .01
-
5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological Changes via RhoA-Dependent Path-ways
Molecules and Cells
2017 .07
-
Dopamine and serotonin alterations by Hizikia fusiformis extracts under in vitro cortical primary neuronal cell cultures
Nutrition Research and Practice
2023 .06
-
Dopamine and serotonin alterations by Hizikia fusiformis extracts under in vitro cortical primary neuronal cell cultures
Nutrition Research and Practice
2023 .06
-
A CoMFA Study of Glycogen Synthase Kinase 3 Inhibitors
조선자연과학논문집
2015 .01
-
A CoMFA Study of Quinazoline-based Anticancer Agents
조선자연과학논문집
2015 .01
-
3D QSAR Studies of Mps1 (TTK) Kinase Inhibitors Based on CoMFA
조선자연과학논문집
2016 .01
-
3D-QSAR Study on Imidazopyridazines Derivatives as Potent Pim-1 Kinase Inhibitors using Region-Focused CoMFA
조선자연과학논문집
2017 .01
-
Fragment based QSAR Analysis of CXCR-2 Inhibitors Using Topomer CoMFA Approach
조선자연과학논문집
2017 .01
-
Comparative Molecular Field Analysis of CXCR-2 Inhibitors
조선자연과학논문집
2016 .01
-
Topomer CoMFA Analysis of Xanthine Oxidase inhibitors
조선자연과학논문집
2017 .01
-
Peripheral Serotonin: a New Player in Systemic Energy Homeostasis
Molecules and Cells
2015 .12
-
QSAR analysis for assessment of the skin irritation potential
한국분석과학회 학술대회
2015 .11
-
Long-term chemical castration induces depressive symptoms by suppressing serotonin expression in rats
Animal cells and systems
2018 .01
-
3D-QSAR Studies on 2-(indol-5-yl)thiazole Derivatives as Xanthine Oxidase (XO) Inhibitors
조선자연과학논문집
2015 .01
-
세로토닌의 생행동 간호연구 적용 가능성 탐색: 문헌분석 연구
Journal of The Korean Data Analysis Society
2021 .08
-
QSAR analysis for predicting acute inhalation toxicity
한국분석과학회 학술대회
2019 .05
-
수용모델을 사용한 우리나라 초미세먼지(PM2.5) 오염원 기여도 연구
한국대기환경학회 학술대회논문집
2017 .11
-
QSAR analysis for predicting the human skin sensitization potential of organic compounds
한국분석과학회 학술대회
2015 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0