지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 408 - 420 (13page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Hizikia fusiformis (HF) is a class of brown seaweeds whose active ingredients exert central nervous system protective effects, such as neuroprotection; however, the underlying mechanisms remain unknown. Given that dopamine (DA) and serotonin (5HT) are two major neurotransmitters involved in various psychiatric disorders and neuronal growth in early neurodevelopmental processes, we investigated whether HF extract could modulate the molecular expression associated with DA and 5HT transmission as well as the structural formation of neurons.
MATERIALS/METHODS: In vitro cell cultures were prepared from cerebral cortical neurons obtained from CD-1 mice on embryonic day 14. Cultured cells were treated with 0.1, 1.0, or 10.0 μg/mL of HT extract for 24 h, followed by fluorescence immunostaining for DA and 5HT-related receptors and transporters and some neuronal structural formation-associated molecules.
RESULTS: HF extract dose-dependently upregulated the expression levels of selective DA and 5HT receptors, and downregulated the levels of DA and 5HT transporters. Moreover, HF extract increased the neurofilament light chain expression.
CONCLUSION: These results suggest that HF may modulate DA and 5HT transmission, thereby affecting neurodevelopment.
MATERIALS/METHODS: In vitro cell cultures were prepared from cerebral cortical neurons obtained from CD-1 mice on embryonic day 14. Cultured cells were treated with 0.1, 1.0, or 10.0 μg/mL of HT extract for 24 h, followed by fluorescence immunostaining for DA and 5HT-related receptors and transporters and some neuronal structural formation-associated molecules.
RESULTS: HF extract dose-dependently upregulated the expression levels of selective DA and 5HT receptors, and downregulated the levels of DA and 5HT transporters. Moreover, HF extract increased the neurofilament light chain expression.
CONCLUSION: These results suggest that HF may modulate DA and 5HT transmission, thereby affecting neurodevelopment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dopamine and serotonin alterations by Hizikia fusiformis extracts under in vitro cortical primary neuronal cell cultures
Nutrition Research and Practice
2023 .06
-
5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological Changes via RhoA-Dependent Path-ways
Molecules and Cells
2017 .07
-
[Notes] Effect of Fluorinated Ligand on the Electrochemical Properties of (Diphosphine)Pt(p-SC6HF₄)₂
대한화학회지
2018 .02
-
3D Structure Prediction of Human 5-Hydroxytryptamine Receptor 7 (5-HT<sub>7</sub>R)
조선자연과학논문집
2018 .01
-
3D QSAR Study of 2-Methoxyphenylpiperazinylakanamides as 5-Hydroxytryptamine (Serotonin) Receptor 7 Antagonists
조선자연과학논문집
2016 .01
-
Antidepressant Effect and Mechanism of Picea mariana Essential Oil on Reserpine-Induced Depression Model Mice
Journal of Microbiology and Biotechnology
2024 .09
-
저농도 HF 표준가스의 안정성 평가
한국대기환경학회 학술대회논문집
2023 .10
-
High performance of inverted polymer solar cells
한국진공학회 학술발표회초록집
2015 .08
-
RAW 264.7 대식세포에서 유산균으로 발효한 다시마와 톳의 항염증 효과
동아시아식생활학회지
2017 .02
-
경쟁적 ELISA를 이용한 도파민과 세로토닌의 검출
대한임상검사과학회지
2017 .01
-
다양한 흡착제를 이용한 HF 가스 처리 소재 평가
한국대기환경학회 학술대회논문집
2018 .10
-
국내산 해조류 4종의 물과 에탄올 추출물이 3T3-L1에서 지방세포 분화에 미치는 영향
동아시아식생활학회지
2015 .12
-
1-Methoxylespeflorin G11 Protects HT22 Cells from Glutamate-Induced Cell Death through Inhibition of ROS Production and Apoptosis
Journal of Microbiology and Biotechnology
2021 .01
-
[Notes] CO 분자와 충돌에 의한 HF(v=3)의 진동이완
대한화학회지
2018 .10
-
저농도 가스상 HF의 분석 효율성 개선
한국분석과학회 학술대회
2023 .11
-
Methylene Blue Reported Electrochemical Aptasensor for Dopamine Detection
한국진공학회 학술발표회초록집
2021 .02
-
고지방식이 유도 비만 마우스에서 아연 보충이 골격 근육의 아연 수송체 ZIP7 수준과 혈당 조절에 미치는 영향
Journal of Nutrition and Health
2021 .12
-
Multidimensional Conducting Polymer Nanofiber Membrane Conjugated with Human Dopamine Receptor for Early Dopamine Detection
한국진공학회 학술발표회초록집
2021 .02
-
A Rotating Flux Pump Employing a Magnetic Circuit and a Stabilized Coated Conductor HTS Stator
Journal of Magnetics
2016 .06
-
Long-term chemical castration induces depressive symptoms by suppressing serotonin expression in rats
Animal cells and systems
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0