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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 529 - 534 (6page)
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초록· 키워드
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Probiotics have been known to reduce high-fat diet (HFD)-induced metabolic diseases, such as obesity, insulin resistance, and type 2 diabetes. We recently observed that Lactobacillus acidophilus NS1 (LNS1), distinctly suppresses increase of blood glucose levels and insulin resistance in HFD-fed mice. In the present study, we demonstrated that oral administration of LNS1 with HFD feeding to mice significantly reduces hepatic expression of phosphoenolpyruvate carboxykinase (PEPCK), a key enzyme in gluconeogenesis which is highly increased by HFD feeding. This suppressive effect of LNS1 on hepatic expression of PEPCK was further confirmed in HepG2 cells by treatment of LNS1 conditioned media (LNS1-CM). LNS1-CM strongly and specifically inhibited $HNF4{\alpha}-induced$ PEPCK promoter activity in HepG2 cells without change of $HNF4{\alpha}$ mRNA levels. Together, these data demonstrate that LNS1 suppresses PEPCK expression in the liver by regulating $HNF4{\alpha}$ transcriptional activity, implicating its role as a preventive or therapeutic approach for metabolic diseases.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Babeu, J. P / 2014 / Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks / World J. Gastroenterol 20:22~30
Cassuto, H. / 2005 / Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit / J. Biol. Chem 280:33873~33884
Gerich, J. E. / 2001 / Renal gluconeogenesis: Its importance in human glucose homeostasis / Diabetes Care 24:382~391
Golozoubova, V. / 2001 / Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold / FASEB J 15:2048~2050
Hemarajata P / 2013 / Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation / Ther. Adv. Gastroenterol 6:39~51
Cassuto, H. / 2005 / Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit / J. Biol. Chem 280:33873~33884
Gerich, J. E. / 2001 / Renal gluconeogenesis: Its importance in human glucose homeostasis / Diabetes Care 24:382~391
Golozoubova, V. / 2001 / Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold / FASEB J 15:2048~2050
Hemarajata P / 2013 / Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation / Ther. Adv. Gastroenterol 6:39~51
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