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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 99 - 109 (11page)
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초록· 키워드
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In this study, we examined the inhibitory effect of L. plantarum Q180 on adipocyte differentiation in 3T3-L1 and reduction of adipocyte size in mice fed high-fat diet. L. plantarum Q180 inhibited the adipocyte differentiation of 3T3-L1 cells ($18.47{\pm}0.32%$) at a concentration of $400{\mu}g/mL$ ($10^8CFU/g$). As a result of western blot analysis, the expression of $C/EBP{\alpha}$ and $PPAR{\gamma}$ in 3T3-L1 adipocyte treated with $400{\mu}g/mL$ of L. plantarum Q180 decreased 35.16% and 40.07%, respectively, compared with the control. To examine the effects, mice were fed three different diets as follows: ND (n=6) was fed ND and orally administered saline solution; HFD (n=6), HFD and orally administered saline solution; and HFD+Q180 (n=6), HFD and orally administered L. plantarum Q180. After six weeks, the rate of increase of body weight was 13.7% lower in the HFD+Q180 group compared to the HFD group. In addition, the epididymal fat weights of the HFD+Q180 group were lower than that of the HFD group. The change of adipocyte size was measured in diet-induced obese mice. Consequently, the number of large-size adipose tissue was less distributed in the ND and HFD+Q180 groups than in the HFD group. L. plantarum Q180 has an effect on the inhibition of 3T3-L1 adipocyte differentiation, fat absorption and reduction of adipocyte size. L. plantarum Q180 could be applied to functional food products that help improve obesity.
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참고문헌 (29)
참고문헌 신청
An HM / 2011 / Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats / Lipids Health Dis 10:116~124
Jasmine Bhathena / 2009 / Orally Delivered Microencapsulated Live Probiotic Formulation Lowers Serum Lipids in Hypercholesterolemic Hamsters / Journal of Medicinal Food 12(2):310~319
Cao Z / 1991 / Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells / Genes Dev 5:1538~1552
Farmer SR / 2006 / Transcriptional control of adipocyte formation / Cell Metab 4:263~273
Funatsu T / 2003 / Experimental model of postprandial hypertriglyceridemia in sucrose-fed rats and the effectiveness of atorvastatin in the model / Metabolism 52:609~615
Jasmine Bhathena / 2009 / Orally Delivered Microencapsulated Live Probiotic Formulation Lowers Serum Lipids in Hypercholesterolemic Hamsters / Journal of Medicinal Food 12(2):310~319
Cao Z / 1991 / Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells / Genes Dev 5:1538~1552
Farmer SR / 2006 / Transcriptional control of adipocyte formation / Cell Metab 4:263~273
Funatsu T / 2003 / Experimental model of postprandial hypertriglyceridemia in sucrose-fed rats and the effectiveness of atorvastatin in the model / Metabolism 52:609~615
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