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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 659 - 664 (6page)
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초록· 키워드
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Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect of Lindera obtusiloba leaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregations in vitro and ex vivo. Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mouse model of pulmonary thromboembolism induced by intravenous injection of a mixture of collagen and epinephrine. Interestingly, LLE did not significantly alter prothrombin time (PT) and activated partial thromboplastin time (aPTT). This study indicates that the antithrombotic effects of LLE might be due to its antiplatelet activities rather than anticoagulation. Taken together, these results suggest that LLE may be a candidate preventive and therapeutic agent in cardiovascular diseases associated with platelet hyperactivity.
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참고문헌 (24)
참고문헌 신청
Ballabeni, V. / 2007 / Antiplatelet and antithrombotic activities of essential oil from wild Ocotea quixos (Lam.) Kosterm. (Lauraceae) calices from Amazonian Ecuador / Pharmacol. Res 55:23~30
Birk, S. / 2006 / The headache-inducing effect of cilostazol in human volunteers / Cephalalgia 26:1304~1309
Bucki, R. / 2003 / Flavonoid inhibition of platelet procoagulant activity and phosphoinositide synthesis / J. Thromb. Haemost 1:1820~1828
CAPRIE Steering Committee / 1996 / A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee / Lancet 348:1329~1339
Francescone, S. / 2008 / “Triple therapy” or triple threat? Balancing the risks of antithrombotic therapy for patients with atrial fibrillation and coronary stents / J. Am. Coll. Cardiol 51:826~827
Birk, S. / 2006 / The headache-inducing effect of cilostazol in human volunteers / Cephalalgia 26:1304~1309
Bucki, R. / 2003 / Flavonoid inhibition of platelet procoagulant activity and phosphoinositide synthesis / J. Thromb. Haemost 1:1820~1828
CAPRIE Steering Committee / 1996 / A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee / Lancet 348:1329~1339
Francescone, S. / 2008 / “Triple therapy” or triple threat? Balancing the risks of antithrombotic therapy for patients with atrial fibrillation and coronary stents / J. Am. Coll. Cardiol 51:826~827
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