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자료유형
학술저널
저자정보
Koo, Tae-Hyeon (Department of Biology, Korea Science Academy) Jun, Hyung-Oh (College of Pharmacy, Seoul National University) Bae, Soo-Kyung (College of Medicine, Pusan National University) Kim, Su-Ryun (College of Dentistry and Research Institute for Oral Biotechnology) Moon, Chang-Pyo (College of Dentistry and Research Institute for Oral Biotechnology) Jeong, Seong-Kyoon (College of Dentistry and Research Institute for Oral Biotechnology) Kim, Woo-Sik (College of Dentistry and Research Institute for Oral Biotechnology) Kim, Gyoo-Cheon (College of Dentistry and Research Institute for Oral Biotechnology) Jang, Hye-Ock (College of Dentistry and Research Institute for Oral Biotechnology) Yun, Il (College of Dentistry and Research Institute for Oral Biotechnology) Kim, Kyu-Won (College of Pharmacy, Seoul National University) Bae, Moon-Kyoung (College of Dentistry and Research Institute for Oral Biotechnology)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제1호
발행연도
2007.1
수록면
34 - 42 (9page)

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Porphyromonas gingivalis is a major periodontal pathogen. The lipopolysaccharide (LPS) secreted from P. gingivalis is implicated in the initiation and progression of periodontitis. Aberrant angiogenesis is often associated with lesion formation in chronic periodontitis. In this study, we report that P. gingivalis LPS activates angiogenic cascade, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs). Furthermore, P. gingivalis LPS potently stimulated in vivo neovascularization in chick chorioallantoic membrane (CAM) and the mouse Matrigel plug assay. P. gingivalis LPS had no effect on the expression of vascular endothelial growth factor (VEGF) or its receptor, Flk-1, implying that P. gingivalis LPS-induced angiogenesis may result from its direct action on endothelial cells. P. gingivalis LPS evoked activation of the mitogen-activated protein kinase ERK1/2 in HUVECs, which is closely linked to angiogenesis. Taken together, these results strongly suggest P. gingivalis LPS plays an important role in the pathological angiogenesis for periodontal diseases, such as periodontitis.

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