지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 141 - 146 (6page)
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초록· 키워드
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Periodontitis is generally a chronic disorder characterized by breakdown of tooth-supporting tissues, producing dentition loss. Porphyromonas gingivalis (P. gingivalis), a Gram- negative anaerobic rod, is one of the major pathogens associated with periodontitis. Neutrophils are first line defense cells in the oral cavity that play a significant role in inflammatory response. Xylitol is a known anti-caries agent and has anti-inflammatory effects. In this study, we conducted experiments to evaluate anti-inflammatory effects of xylitol on P. gingivalis infected neutrophils for possible usage in prevention and treatment of periodontal infections. P. gingivalis was intraperitoneally injected and peritoneal lavage was collected for cytokine determination. For in vitro study, neutrophils were collected from mouse peritoneal cells after zymosan injection or bone marrow cells. Neutrophils were stimulated with live P. gingivalis and ELISA was used to determine the effect of xylitol on P. gingivalis induced cytokine production. IL-1β, IL-6, TNF-α concentration and neutrophil population in the peritoneal lavage was increased in P. gingivalis-infected mouse. Peritoneal cells infected with live P. gingivalis revealed significantly increased production of IL-1β, IL-6 and TNF-α at multiplicity of infection of 10. Neutrophils from bone marrow and peritoneal lavage revealed increased production of IL-1β, IL-6 and TNF-α. Xylitol significantly mitigated P. gingivalis induced cytokine production in neutrophils. Findings indicate that xylitol is an anti-inflammatory agent in neutrophils infected with live P.gingivalis, that suggests its use in periodontitis management.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Medzhitov R / 2008 / Origin and physiological roles of inflammation / Nature 454:428~435
Socransky SS / 1992 / The bacterial etiology of destructive periodontal disease: current concepts / J Periodontol 63:322~331
Byrne SJ / 2009 / Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque / Oral Microbiol Immunol 24:469~477
Chen GY / 2010 / Sterile inflammation: sensing and reacting to damage / Nat Rev Immunol 10:826~837
Delima AJ / 2003 / Origin and function of the cellular components in gingival crevice fluid / Periodontol 2000 31:55~76
Socransky SS / 1992 / The bacterial etiology of destructive periodontal disease: current concepts / J Periodontol 63:322~331
Byrne SJ / 2009 / Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque / Oral Microbiol Immunol 24:469~477
Chen GY / 2010 / Sterile inflammation: sensing and reacting to damage / Nat Rev Immunol 10:826~837
Delima AJ / 2003 / Origin and function of the cellular components in gingival crevice fluid / Periodontol 2000 31:55~76
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