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Reactive oxygen species (ROS) are produced in the metabolic process of oxygen in cells. The superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in cells systemize the antioxidant enzymes to control the oxidative stress. Genistein is one of the isoflavonoids, and its role in controlling cellular oxidative stress is presently the active issue at question. In this study; we analyzed genistein-induced survival rates of the CHO-K1 cells, activities of antioxidant enzymes, ROS levels, and expression levels of antioxidant enzyme genes in order to investigate the effect of genistein on cellular ROS production and antioxidative systems in CHO-K1 cells. As results, the survival rate of cells was decreased as the dose of genistein increases (12.5${\sim}$200 ${\mu}$M). Genistein increased cellular ROS levels, while it reduced total SOD activities and the expression of CuZnSOD. In conclusion, we suggest that genistein may induce oxidative stress via down-regulation of SOD.
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미성숙 암컷 흰쥐의 성 성숙에 미치는 genistein의 효과
Clinical and Experimental Pediatrics
2009 .01
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Molecular Effects of Genistein on Proliferation and Apoptosis of MCF-7 Cell Line
Molecular & cellular toxicology
2006 .01
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Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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Genistein이 유방암예방 활성에 미치는 영향
동의생리병리학회지
2006 .01
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Genistein 에 의한 B35 신경모세포종 세포의, 세포자멸사유도 및 세포주기 정지; p21waf1/cip1, Bax와 Bcl-2의 관련
Journal of Pathology and Translational Medicine
2006 .01
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Genistein이 유방암예방 활성에 미치는 영향
동의생리병리학회지
2006 .02
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Effect of Genistein on the Aryl Hydrocarbon Receptor and Cytochrome P450 1A1 in MCF-7 Human Breast Carcinoma Cells
Environmental Analysis Health and Toxicology
2006 .03
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Pharmaceutical Evaluation of Genistein-loaded Pluronic Micelles for Oral Delivery
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice
한국실험동물학회 학술발표대회 논문집
2013 .08
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Preferential Cytotoxic Effect of Genistein on G361 Melanoma Cells Via Inhibition of the Expression of Focal Adhesion Kinase
International Journal of Oral Biology
2012 .01
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햄스터 난소세포에서 Daidzein과 Genistein에 의해 유도된 산화적 스트레스에 대한 Vitamin C의 효과
약학회지
2007 .01
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Synthesizing efficacious genistein in conjugation with superparamagnetic Fe3O4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma
생체재료학회지
2020 .01
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Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models
Laboratory Animal Research
2014 .12
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Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice
한국실험동물학회 학술발표대회 논문집
2012 .08
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Genistein이 T lymphocyte의 Apoptosis 및 복강 Macrophage의 탐식능에 미치는 영향
약학회지
2002 .01
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Osteogenic Activities of Genistein Derivatives were Influenced by the Presence of Prenyl Group at Ring A
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
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Effects of Genistein on the Proliferation and Differentiation in Rat Dental Pulp Cells
대한치과재료학회 학술대회
2011 .05
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GENISTEIN INHIBITS $NF-_kB-DEPENDENT$ COX-2 INDUCTION IN HUMAN BREAST EPITHELIAL CELLS BY MODULATING THE ACTIVATION OF TATA-BINDING PROTEIN
대한약학회 학술대회
2002 .01
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