지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 179 - 185 (7page)
이용수
초록· 키워드
오류제보하기
Adenine, a purine base, is a structural component of essential biomolecules such as nucleic acids and adenine nucleotides. Its physiological roles have been uncovered. Adenine suppresses IgE-mediated allergy and LPS-induced inflammation. Although adenine is known to inhibit lymphocyte proliferation, the effect of adenine to melamoma cells is not reported. Here, we investigated the growth inhibitory effects of adenine on B16-F10 mouse melanoma cells. Adenine suppressed the proliferation of B16-F10 cells in dose-dependent manner with the maximal inhibitory dose of 2 mM. Adenine treatment induced cell death molecular markers such as PARP and caspase 3 cleavages. Pan-caspase inhibitor z-VAD dramatically rescued the cell death molecular markers, cell proliferation recovered marginally. These results provide the possibility of adenine to be used as an anti-tumor agent.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Avila MA / 2004 / Methylthioadenosine / Int J Biochem Cell Biol 36:2125~2130
Cheng YF / 2015 / Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells / PLoS One 10:e0142283
Cory S / 2002 / The Bcl2 family: regulators of the cellular life-or-death switch / Nat Rev Cancer 2:647~656
Elmore S / 2007 / Apoptosis : a review of programmed cell death / Toxicol Pathol 35:495~516
Engle SJ / 1996 / Adenine phosphoribosyltransferase-deficient mice develop 2, 8-dihydroxyadenine nephrolithiasis / Proc Natl Acad Sci U S A 93:5307~5312
Cheng YF / 2015 / Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells / PLoS One 10:e0142283
Cory S / 2002 / The Bcl2 family: regulators of the cellular life-or-death switch / Nat Rev Cancer 2:647~656
Elmore S / 2007 / Apoptosis : a review of programmed cell death / Toxicol Pathol 35:495~516
Engle SJ / 1996 / Adenine phosphoribosyltransferase-deficient mice develop 2, 8-dihydroxyadenine nephrolithiasis / Proc Natl Acad Sci U S A 93:5307~5312
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Adenine attenuates lipopolysaccharide-induced inflammatory reactions
The Korean Journal of Physiology & Pharmacology
2018 .07
-
Adenine Induces Apoptosis Markers in B16-F10 Melanoma Cells: Inhibiting Akt and mTOR and Increasing Bax/Bcl-2 Ratio
대한의생명과학회지
2023 .09
-
Effect of Adenine on Clozapine-induced Neutropenia in Patients with Schizophrenia: A Preliminary Study
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Melanoma Cell Death Mechanisms
전남의대학술지
2018 .01
-
MicroRNA-328 Inhibits Proliferation of Human Melanoma Cells by Targeting TGFB2
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
Immune Network
2015 .04
-
The growth- and migration-inhibitory effect of Lactobacillus plantarum L14 cell-free extract on human malignant melanoma cells
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells : Their Effects on Host Cell Proliferation and Cell Cycle Changes
Parasites, Hosts and Diseases
2016 .04
-
Cell Death and Liver Disease
Gut and Liver
2020 .01
-
Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation
Immune Network
2020 .10
-
SD-317 inhibits cell growth and proliferation by preventing activation of Akt in lung cancer
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Inhibitory effect of gastrodin and 4-hydroxybenzyl alcohol on tumor cell proliferation
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Humic Substances Suppresses the Proliferation of TC-1 Cells, the Lung Cancer Cell
대한의생명과학회지
2023 .12
-
Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis
Journal of Ginseng Research
2021 .01
-
Paracrine influence of human perivascular cells on the proliferation of adenocarcinoma alveolar epithelial cells
The Korean Journal of Physiology & Pharmacology
2017 .03
-
Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Anticancer Drugs at Low Concentrations Upregulate the Activity of Natural Killer Cell
대한의생명과학회지
2023 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-510-001306026