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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.47 No.3
- 발행연도
- 2020.9
- 수록면
- 497 - 508 (12page)
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초록· 키워드
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In this study, we investigated the protective effects of ‘Donganme’ (Sorghum bicolor L. Moench) against oxidative stress under in vitro conditions and in a cellular system using C6 glial cells. The radical scavenging activities were observed using the substrates 1,1-diphenyl-2- picrylhydrazyl (DPPH) and hydroxyl (•OH) radicals. The Donganme extract had an •OH radical scavenging activity of 82.66% at a concentration of 100 μg·mL<SUP>-1</SUP>. Additionally, when DPPH was used as the substrate, the Donganme extract exhibited a strong radical scavenging activity in a concentration-dependent manner with an IC<SUB>50</SUB> value of 28.56 μg·mL<SUP>-1</SUP>. Furthermore, treating C6 glial cells with hydrogen peroxide (H₂O₂) reduced the cell viability and generated reactive of oxygen species (ROS) and lactate dehydrogenase (LDH) compared to the normal levels, indicating that H₂O₂ induced oxidative stress. However, Donganme extracts increased the cell viability and inhibited ROS and LDH production against oxidative stress by H₂O₂ in the C6 glial cells. In particular, it showed effective cell protection with the cell viability, ROS production, and LDH release at 83.50, 88.06, and 14.87%, respectively, which were lower than the control or similar to the normal levels even at a low concentration of 100 μg·mL<SUP>-1</SUP>. The present study suggests that the Donganme extract was effective in protecting against oxidative stress in C6 glial cells through its antioxidant activity. Thus, Donganme could be a promising therapeutic agent for neurodegenerative diseases due to oxidative stress.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (46)
참고문헌 신청
Afify AEMMR / 2011 / Bioavailability of iron, zinc, phytate and phytase activity during soaking and germination of white sorghum varieties / PLOS ONE 6:e25512
Afify AEMMR / 2012 / Biochemical changes in phenols, flavonoids, tannins, vitamin E, β–carotene and antioxidant activity during soaking of three white sorghum varieties / Asian Pacific Journal of Tropical Biomedicine 2:203~209
Awika JM / 2004 / Sorghum phytochemicals and their potential impact on human health / Phytochemistry 65:1199~1221
Cathcart R / 1983 / Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay / Analytical Biochemistry 134:111~116
Cetin D / 2015 / The in vitro protective effect of salicylic acid against paclitaxel and cisplatin-induced neurotoxicity / Cytotechnology 68:1361~1367
Afify AEMMR / 2012 / Biochemical changes in phenols, flavonoids, tannins, vitamin E, β–carotene and antioxidant activity during soaking of three white sorghum varieties / Asian Pacific Journal of Tropical Biomedicine 2:203~209
Awika JM / 2004 / Sorghum phytochemicals and their potential impact on human health / Phytochemistry 65:1199~1221
Cathcart R / 1983 / Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay / Analytical Biochemistry 134:111~116
Cetin D / 2015 / The in vitro protective effect of salicylic acid against paclitaxel and cisplatin-induced neurotoxicity / Cytotechnology 68:1361~1367
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