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논문 기본 정보

자료유형
학술저널
저자정보
Ji Myung Choi (Pusan National University) Yeo Jin Kim (Pusan National University) Ah Young Lee (Gyeongnam National University of Science and Technology) Eun Ju Cho (Pusan National University)
저널정보
충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.47 No.3
발행연도
2020.9
수록면
497 - 508 (12page)

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초록· 키워드

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In this study, we investigated the protective effects of ‘Donganme’ (Sorghum bicolor L. Moench) against oxidative stress under in vitro conditions and in a cellular system using C6 glial cells. The radical scavenging activities were observed using the substrates 1,1-diphenyl-2- picrylhydrazyl (DPPH) and hydroxyl (•OH) radicals. The Donganme extract had an •OH radical scavenging activity of 82.66% at a concentration of 100 μg·mL<SUP>-1</SUP>. Additionally, when DPPH was used as the substrate, the Donganme extract exhibited a strong radical scavenging activity in a concentration-dependent manner with an IC<SUB>50</SUB> value of 28.56 μg·mL<SUP>-1</SUP>. Furthermore, treating C6 glial cells with hydrogen peroxide (H₂O₂) reduced the cell viability and generated reactive of oxygen species (ROS) and lactate dehydrogenase (LDH) compared to the normal levels, indicating that H₂O₂ induced oxidative stress. However, Donganme extracts increased the cell viability and inhibited ROS and LDH production against oxidative stress by H₂O₂ in the C6 glial cells. In particular, it showed effective cell protection with the cell viability, ROS production, and LDH release at 83.50, 88.06, and 14.87%, respectively, which were lower than the control or similar to the normal levels even at a low concentration of 100 μg·mL<SUP>-1</SUP>. The present study suggests that the Donganme extract was effective in protecting against oxidative stress in C6 glial cells through its antioxidant activity. Thus, Donganme could be a promising therapeutic agent for neurodegenerative diseases due to oxidative stress.

목차

Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References

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