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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 315 - 321 (7page)
- DOI
- 10.7783/KJMCS.2017.25.5.315
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초록· 키워드
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Background: Glycyrrhiza uralensis Radix (GR) is a crude drugs used in Asian countries that has been reported to prevent the progression of neurodegenerative diseases such as Alzheimer’s disease. The present study examined whether GR and its active compounds, glycyrrhizic acid (GA) and isoliquiritigenin (IL), exerted protective effects on H₂O₂-induced oxidative damage in C6 glial cells.Methods and Results: We exposed C6 glial cells to hydrogen peroxide (H₂O₂) for 24 h and investigated the cellular response to GR and its active compounds by evaluating cell viability, reactivie oxygen species (ROS) production, and apoptosis-related protein expression. GR successfully mitigated the reduced cell viability and ROS production induced by H₂O₂ in C6 glial cells, IL and GA significantly increased the cell viability and decreased ROS production. In addition, IL and GA down-regulated apoptotic Baxdependent caspase-3 activation, but each compound exerted different mechanisms, i.e., IL dose-dependently decreased ROS production and, GA up-regulated anti-apoptotic Bcl-2 expression.Conclusions: These results demonstrated that GR and its active components, IL and GA, exhibit potential for use as natural neurodegenerative agents for the modulation of apoptosis in C6 glial cells.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Ahn J / 2006 / Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by β-amyloid peptide 25-35 in young mice / Biogerontology 7:239~247
Asl MN / 2008 / Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds / Phytotherapy Research 22:709~724
Behl C / 1994 / Hydrogen peroxide mediates amyloid beta protein toxicity / Cell 77:817~827
de Bernardo S / 2004 / Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures / Journal of Neurochemistry 91:667~682
Desagher S / 1996 / Astrocytes protect neurons from hydrogen peroxide toxicity / The Journal of Neuroscience 16:2553~2562
Asl MN / 2008 / Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds / Phytotherapy Research 22:709~724
Behl C / 1994 / Hydrogen peroxide mediates amyloid beta protein toxicity / Cell 77:817~827
de Bernardo S / 2004 / Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures / Journal of Neurochemistry 91:667~682
Desagher S / 1996 / Astrocytes protect neurons from hydrogen peroxide toxicity / The Journal of Neuroscience 16:2553~2562
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UCI(KEPA) : I410-ECN-0101-2019-480-000585694