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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 91 - 98 (8page)
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초록· 키워드
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Stichopus japonicas (red sea cucumbers) inhabit the coastal sea surrounding Jeju Island, South Korea, and are thought to have various medicinal properties. In this study, we investigated the anticancer activity of a red sea cucumber (S. japonicus) collected from Jeju Island. We obtained the red sea cucumber extract (RSCE), and observed that it inhibited the tumor cell growth and increased reactive oxygen species (ROS) production associated with the induction of apoptosis through the mitogen-activated protein kinase (MAPK) pathway in murine colon carcinoma cells (CT-26). Treatment with RSCE and N-acetylcysteine, which is a ROS scavenger, increased ROS production and apoptosis via the regulation by the MAPK pathway on the ERK and JNK compared with the nontreated group. Therefore, RSCE promotes ROS-mediated suppression of the ERK and JNK activation, and subsequently inhibits cancer progression, suggesting that RSCE may be beneficial in treating colon carcinoma.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (33)
참고문헌 신청
Ahmedin Jemal / 2011 / Global cancer statistics / CA : a cancer journal for clinicians 61(2):69~90
Allal Ouhtit / 2013 / Simultaneous inhibit ion of cell-cycle, proliferation, survival, metastatic pathways and induction of apoptosis in breast cancer cells by a phytochemical super-cocktail: Genes that underpin its mode of action / Journal of Cancer 4(9):703
Atsushi Matsuzawa and Hidenori Ichijo / 2005 / Stress -responsive protein kinases in redox-regulated apopt osis signaling / ntioxidants & redox signaling 7(3-4):472~481
Bobbili V.V / 2003 / Phycocyanin-mediated apoptosis in ak-5 tumor cells involves down-regulation of bcl-2 and generation of ros / Molecular cancer therapeutics 2(11):1165~1170
Chong Sun / 2014 / Feedback and redundancy in receptor tyrosine kinase signaling: Rel evance to cancer therapies / Trends in biochemical sci ences 39(10):465~474
Allal Ouhtit / 2013 / Simultaneous inhibit ion of cell-cycle, proliferation, survival, metastatic pathways and induction of apoptosis in breast cancer cells by a phytochemical super-cocktail: Genes that underpin its mode of action / Journal of Cancer 4(9):703
Atsushi Matsuzawa and Hidenori Ichijo / 2005 / Stress -responsive protein kinases in redox-regulated apopt osis signaling / ntioxidants & redox signaling 7(3-4):472~481
Bobbili V.V / 2003 / Phycocyanin-mediated apoptosis in ak-5 tumor cells involves down-regulation of bcl-2 and generation of ros / Molecular cancer therapeutics 2(11):1165~1170
Chong Sun / 2014 / Feedback and redundancy in receptor tyrosine kinase signaling: Rel evance to cancer therapies / Trends in biochemical sci ences 39(10):465~474
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UCI(KEPA) : I410-ECN-0101-2021-472-001410933