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논문 기본 정보

자료유형
학술저널
저자정보
Hamideh Najjarpour Jabbari (Tabriz University of Medical Sciences) Mohammad Shabani (Tabriz University of Medical Sciences) Farnaz Monajjemzadeh (Tabriz University of Medical Sciences)
저널정보
한국분석과학회 분석과학 분석과학 제34권 제2호
발행연도
2021.4
수록면
46 - 55 (10page)

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초록· 키워드

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Evaluation of drug-excipient compatibility is one of the basic steps in the preformulation of pharmaceutical dosage forms. Some reactive excipients have been known so far which may cause stability problems for drug molecules in pharmaceutical dosage forms. The aim of this study was to evaluate drug-excipient compatibility of gliclazide with some common pharmaceutical excipients, known for their ability to incorporate in drug-excipient interactions. Binary mixtures were prepared using lactose, magnesium stearate, polyvinylpyrrolidone, sodium starch glycolate, polyethylene glycol 2000 and dicalcium phosphate. Based on the results; gliclazide was incompatible with all tested excipients; but not with dicalcium phosphate. DSC (Differential Scanning Calorimetry) results were in accordance with HPLC (High Pressure liquid chromatography) data and were more predictive than FTIR (Fourier Transform Infrared Spectroscopy). Drug and reactive excipients incompatibility was fully discussed and documented. It is advisable to avoid incompatible excipients or carefully monitor the drug stability when incorporating such excipients in final formulation designs.

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Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References

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