지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Hot stage microscopy (HSM) is a thermal analysis technique that combines the best properties of thermal analysis and microscopy. HSM is rapidly gaining interest in pharmaceuticals as well as in other fields as a regular characterization technique. In pharmaceuticals HSM is used to support differential scanning calorimetry (DSC) and thermo-gravimetric analysis (TGA) observations and to detect small changes in the sample that may be missed by DSC and TGA during a thermal experiment. Study of various physical and chemical properties such sample morphology, crystalline nature, polymorphism, desolvation, miscibility, melting, solid state transitions and incompatibility between various pharmaceutical compounds can be carried out using HSM. HSM is also widely used to screen cocrystals, excipients and polymers for solid dispersions. With the advancements in research methodologies, it is now possible to use HSM in conjunction with other characterization techniques such as Fourier transform infrared spectroscopy (FTIR), DSC, Raman spectroscopy, scanning electron microscopy (SEM) which may have additional benefits over traditional characterization techniques for rapid and comprehensive solid state characterization.
목차
등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
S. Aitipamula / 2012 / Cocrystal hydrate of an antifungal drug, griseofulvin, with promising physicochemical properties / Cryst. Growth Des 12(12):5858~5863
S. Aitipamula / 2012 / Polymorphism and phase transformations of a cocrystal of nicotinamide and pimelic acid / CrystEngComm 14(23):8193~8198
M. Alhijjaj / 2015 / Thermal analysis by structural characterization as a method for assessing heterogeneity in complex solid pharmaceutical dosage forms / Anal. Chem 87(21):10848~10855
G. P. Ashton / 2017 / An integrated hot-stage microscope–direct analysis in real time–mass spectrometry system for studying the thermal behavior of materials / Anal. Chem 89(24):13466~13471
N. J. Babu / 2012 / Crystal engineering of stable temozolomide cocrystals / Chem. Asian J 7(10):2274~2285
S. Aitipamula / 2012 / Polymorphism and phase transformations of a cocrystal of nicotinamide and pimelic acid / CrystEngComm 14(23):8193~8198
M. Alhijjaj / 2015 / Thermal analysis by structural characterization as a method for assessing heterogeneity in complex solid pharmaceutical dosage forms / Anal. Chem 87(21):10848~10855
G. P. Ashton / 2017 / An integrated hot-stage microscope–direct analysis in real time–mass spectrometry system for studying the thermal behavior of materials / Anal. Chem 89(24):13466~13471
N. J. Babu / 2012 / Crystal engineering of stable temozolomide cocrystals / Chem. Asian J 7(10):2274~2285
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