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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.100 No.6
- 발행연도
- 2021.6
- 수록면
- 320 - 328 (9page)
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초록· 키워드
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Purpose: Laparoscopic distal pancreatectomy (LDP) is widely performed but its efficacy and safety are not established for malignant lesions. This study was aimed to compare outcomes of LDP and open distal pancreatectomy (ODP) in pancreatic ductal adenocarcinoma (PDAC).
Methods: Patients who underwent distal pancreatectomy for PDAC between 2009 and 2017 were enrolled. The preoperative clinical stage was evaluated and propensity score matching (PSM) was performed using age, sex, The American Joint Committee on Cancer 8th clinical T stage, and other organ involvement.
Results: In 186 patients enrolled, 35 (18.8%) received LDP. The ODP group showed larger tumor size and frequent involvement of other organs in preoperative images. However, after PSM, these differences were balanced. R0 resection (90.5% vs. 94.3%, P = 0.730), harvested lymph nodes (14.3 vs. 12.6, P = 0.380) and pathologic T stage (P = 0.474) were comparable between ODP and LDP groups, respectively. LDP demonstrated shorter operation time, less postoperative pain, and shorter hospitalization (14.4 days vs. 11.1 days, P = 0.026). In terms of long-term oncologic outcomes, median overall survival (32 months vs. 28 months, P = 0.724) and disease-free survival (18 months vs. 19 months, P = 0.926) were comparable.
Conclusion: LDP demonstrated better short-term outcomes and comparable long-term outcomes compared with ODP. LDP is a safe and feasible procedure for PDAC.
Methods: Patients who underwent distal pancreatectomy for PDAC between 2009 and 2017 were enrolled. The preoperative clinical stage was evaluated and propensity score matching (PSM) was performed using age, sex, The American Joint Committee on Cancer 8th clinical T stage, and other organ involvement.
Results: In 186 patients enrolled, 35 (18.8%) received LDP. The ODP group showed larger tumor size and frequent involvement of other organs in preoperative images. However, after PSM, these differences were balanced. R0 resection (90.5% vs. 94.3%, P = 0.730), harvested lymph nodes (14.3 vs. 12.6, P = 0.380) and pathologic T stage (P = 0.474) were comparable between ODP and LDP groups, respectively. LDP demonstrated shorter operation time, less postoperative pain, and shorter hospitalization (14.4 days vs. 11.1 days, P = 0.026). In terms of long-term oncologic outcomes, median overall survival (32 months vs. 28 months, P = 0.724) and disease-free survival (18 months vs. 19 months, P = 0.926) were comparable.
Conclusion: LDP demonstrated better short-term outcomes and comparable long-term outcomes compared with ODP. LDP is a safe and feasible procedure for PDAC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
Kim HH / 2010 / Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report. A phase III multicenter, prospective, randomized trial (KLASS Trial) / Ann Surg 251:417~420
Viñuela EF / 2012 / Laparoscopic versus open distal gastrectomy for gastric cancer : a meta-analysis of randomized controlled trials and high-quality nonrandomized studies / Ann Surg 255:446~456
Bonjer HJ / 2015 / A randomized trial of laparoscopic versus open surgery for rectal cancer / N Engl J Med 372:1324~1332
Hasegawa H / 2003 / Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer / Surg Endosc 17:636~640
Kennedy RH / 2014 / Multicenter randomized controlled trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme : EnROL / J Clin Oncol 32:1804~1811
Viñuela EF / 2012 / Laparoscopic versus open distal gastrectomy for gastric cancer : a meta-analysis of randomized controlled trials and high-quality nonrandomized studies / Ann Surg 255:446~456
Bonjer HJ / 2015 / A randomized trial of laparoscopic versus open surgery for rectal cancer / N Engl J Med 372:1324~1332
Hasegawa H / 2003 / Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer / Surg Endosc 17:636~640
Kennedy RH / 2014 / Multicenter randomized controlled trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme : EnROL / J Clin Oncol 32:1804~1811
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