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The S100 family proteins act as inducers of cancer cell apoptosis and inflammatory mediators. This study examined the pro-apoptotic mechanism caused by S100A8 and S100A9 in human FIP1L1-PDGFRα-positive eosinophilic leukemia cells. S100A8 and S100A9 elicited the death of EoL-1 cells in a time and dose-dependent manner. The activation of PDGFRα was suppressed by a decrease in PDGFRα after treatment with S100A8 and S100A9. Cycloheximide, a translation inhibitor, suppressed PDGFRα expression from 1 h to 5 h, and a co-treatment with S100A8 and S100A9 boosted the decrease in expression. The phosphorylation and expression of STAT5 decreased after treatment with S100A8 and S100A9 in EoL-1 and imatinib-resistant (EoL-1-IR) cells. S100A8 and S100A9 induced the chemotaxis of EoL-1 cells but did not affect the chemoattraction of EoL-1-IR. These findings indicate the cell death mechanism due to S100 family proteins and the development of leukemia therapy using S100A8 and S100A9.
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참고문헌 (11)
참고문헌 신청
Bresnick, AR / 2015 / S100 proteins in cancer / Nature Review Cancer 15:96~109
Donato R / 2013 / Functions of S100 proteins / Current Molecular Medicine 13:24~57
Goyette J / 2011 / Inflammation-associated S100 proteins : new mechanisms that regulate function / Amino Acids 41:821~842
Kim IS / 2005 / Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells / FEBS Letters 579:6044~6048
김인식 / 2017 / S100A8 and S100A9 Secreted by Allergens in Monocytes Inhibit Spontaneous Apoptosis of Normal and Asthmatic Neutrophils via the Lyn/Akt/ERK Pathway / 대한임상검사과학회지 49(2):128~134
Donato R / 2013 / Functions of S100 proteins / Current Molecular Medicine 13:24~57
Goyette J / 2011 / Inflammation-associated S100 proteins : new mechanisms that regulate function / Amino Acids 41:821~842
Kim IS / 2005 / Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells / FEBS Letters 579:6044~6048
김인식 / 2017 / S100A8 and S100A9 Secreted by Allergens in Monocytes Inhibit Spontaneous Apoptosis of Normal and Asthmatic Neutrophils via the Lyn/Akt/ERK Pathway / 대한임상검사과학회지 49(2):128~134
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