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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 426 - 429 (4page)
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Chronic eosinophilic leukemia (CEL) is characterized by eosinophilia and organ damage. Imatinib is widely used for treating CEL, chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Unfortunately, the cancer cells gain resistance against the drug after prolonged molecular-targeted therapies. Imatinib-resistant EoL-1 (EoL-1-IR) cells were produced from chronic eosinophilic leukemia cells (EoL-1) after treatment with imatinib for a long duration. Twodimensional electrophoresis (2-DE) analysis revealed numerous protein variations in the EoL-1 and EoL-1-IR sub-types. Compared to the EoL-1 cells, expression levels of TIP49, RBBP7, α-enolase, adenosine deaminase, C protein, galactokinase, eukaryotic translation initiation factor, IFN-γ, and human protein homologous to DROER were increased, whereas core I protein, proteasome subunit p42, heterogeneous ribonuclear particle protein, chain B, and nucleoside diphosphate were decreased in the EoL-1-IR cells. Taken together, these results contribute to understanding the pathogenic mechanism of drug-resistant diseases.
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참고문헌 (9)
참고문헌 신청
[학술지(정기간행물)] - Antoniu SA / 2010 / Novel therapies for hypereosinophilic syndromes / Neth J Med 68 : 304 ~ 310
[학술지(정기간행물)] - 김인식 / 2017 / The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1 / 대한의생명과학회지 23 (1) : 44 ~ 47
[학술지(정기간행물)] - Klion AD / 2015 / How I treat hypereosinophilic syndromes / Blood 126 : 1069 ~ 1077
[학술지(정기간행물)] - Metzgeroth G / 2008 / Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study / Br J Haematol 143 : 707 ~ 715
[학술지(정기간행물)] - Nishioka C / 2010 / Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene / Leukemia 24 : 1631 ~ 1640
[학술지(정기간행물)] - 김인식 / 2017 / The Role of S100A8 and S100A9 in Differentiation of Human Eosinophilic Leukemia Cells, EoL-1 / 대한의생명과학회지 23 (1) : 44 ~ 47
[학술지(정기간행물)] - Klion AD / 2015 / How I treat hypereosinophilic syndromes / Blood 126 : 1069 ~ 1077
[학술지(정기간행물)] - Metzgeroth G / 2008 / Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study / Br J Haematol 143 : 707 ~ 715
[학술지(정기간행물)] - Nishioka C / 2010 / Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene / Leukemia 24 : 1631 ~ 1640
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UCI(KEPA) : I410-ECN-0101-2019-510-000302712