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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 14 - 31 (18page)
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초록· 키워드
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Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper and lower airways constitute a unique system and their interaction shows functional complementarity. Although human upper airway contains various indigenous commensals and opportunistic pathogenic microbiome, imbalance of this interactions lead to pathogen overgrowth and increased inflammation and airway remodeling. Competition for epithelial cell attachment, different susceptibilities to host defense molecules and antimicrobial peptides, and the production of proinflammatory cytokine and pattern recognition receptors possibly determine the pattern of this inflammation. Exposure to environmental factors, including infection, air pollution, smoking is commonly associated with asthma comorbidity, severity, exacerbation and resistance to anti-microbial and steroid treatment, and these effects may also be modulated by host and microbial genetics. Administration of probiotic, antibiotic and corticosteroid treatment for asthma may modify the composition of resident microbiota and clinical features. This review summarizes the effect of some environmental factors on the upper respiratory microbiome, the interaction between host-microbiome, and potential impact of asthma treatment on the composition of the upper airway microbiome.
목차
ABSTRACT
INTRODUCTION
AIRWAY INFLAMMATION AND ASTHMA PHENOTYPES
HOST-MICROBIOTA AND INTERRELATIONSHIPS BETWEEN MICROBIOTA
NORMAL UPPER AIRWAY MICROBIOTA
INFLUENTIAL FACTORS ON THE COMPOSITION OF UPPER AIRWAY MICROBIOME
MICROBIOTA COMPOSITION IN UPPER AIRWAY DISEASE
UPPER AIRWAY MICROBIOTA IN ADULT ASTHMA
THERAPEUTIC EFFECT ON THE COMPOSITION OF UPPER AIRWAY MICROBIOTA
CONCLUDING REMARKS
REFERENCES
참고문헌 (111)
참고문헌 신청
Global Asthma Network / 2018 / The Global Asthma Report
Kang SY / 2018 / Time trends of the prevalence of allergic diseases in Korea : a systematic literature review / Asia Pac Allergy 8:e8
Pakkasela J / 2020 / Age-specific incidence of allergic and non-allergic asthma / BMC Pulm Med 20:9
Song WJ / 2017 / Respiratory allergies in the elderly : findings from the Korean Longitudinal Study on Health and Aging phase I study(2005–2006) / Asia Pac Allergy 7:185~192
Holgate ST / 2010 / A look at the pathogenesis of asthma: the need for a change in direction / Discov Med 9:439~447
Kang SY / 2018 / Time trends of the prevalence of allergic diseases in Korea : a systematic literature review / Asia Pac Allergy 8:e8
Pakkasela J / 2020 / Age-specific incidence of allergic and non-allergic asthma / BMC Pulm Med 20:9
Song WJ / 2017 / Respiratory allergies in the elderly : findings from the Korean Longitudinal Study on Health and Aging phase I study(2005–2006) / Asia Pac Allergy 7:185~192
Holgate ST / 2010 / A look at the pathogenesis of asthma: the need for a change in direction / Discov Med 9:439~447
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UCI(KEPA) : I410-ECN-0101-2021-517-001845492