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자료유형
학술저널
저자정보
Soyoon Sim (Ajou University School of Medicine) Youngwoo Choi (Ajou University School of Medicine) Hae-Sim Park (Ajou University School of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.22 No.6
발행연도
2022.12
수록면
29 - 43 (15page)

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초록· 키워드

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Asthma is a chronic airway inflammatory disease characterized by reversible airway obstruction and airway hyperreactivity to various environmental stimuli, leading to recurrent cough, dyspnea, and wheezing episodes. Regarding inflammatory mechanisms, type 2/eosinophilic inflammation along with activated mast cells is the major one; however, diverse mechanisms, including structural cells-derived and non-type 2/neutrophilic inflammations are involved, presenting heterogenous phenotypes. Although most asthmatic patients could be properly controlled by the guided treatment, patients with severe asthma (SA; classified as a treatmentrefractory group) suffer from uncontrolled symptoms with frequent asthma exacerbations even on regular anti-inflammatory medications, raising needs for additional controllers, including biologics that target specific molecules found in asthmatic airway, and achieving the precision medicine for asthma. This review summarizes the immunologic basis of airway inflammatory mechanisms and current biologics for SA in order to address unmet needs for future targets.

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ABSTRACT
INTRODUCTION
ASTHMA PHENOTYPES
ASTHMA AND IMMUNE CELLS
BIOLOGICS FOR THE TREATMENT OF SA
FUTURE DIRECTIONS
REFERENCES

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