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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 105 - 117 (13page)
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초록· 키워드
오류제보하기
Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
Park CG / 2009 / Current status and future perspectives of xenotransplantation / J Korean Soc Transplant 23:203~213
김재환 / 2013 / 수혈요법의 최신지견 / 대한의사협회지 56(6):496~503
Kresie L / 2001 / Artificial blood : an update on current red cell and platelet substitutes / Proc Bayl Univ Med Cent 14:158~116
Cooper DK / 2012 / A brief history of cross-species organ transplantation / Proc Bayl Univ Med Cent 25:49~57
Moradi S / 2016 / Artificial blood substitutes : first steps on the long route to clinical utility / Clin Med Insights Blood Disord 9:33~41
김재환 / 2013 / 수혈요법의 최신지견 / 대한의사협회지 56(6):496~503
Kresie L / 2001 / Artificial blood : an update on current red cell and platelet substitutes / Proc Bayl Univ Med Cent 14:158~116
Cooper DK / 2012 / A brief history of cross-species organ transplantation / Proc Bayl Univ Med Cent 25:49~57
Moradi S / 2016 / Artificial blood substitutes : first steps on the long route to clinical utility / Clin Med Insights Blood Disord 9:33~41
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UCI(KEPA) : I410-ECN-0101-2021-517-001845447