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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 108 - 110 (3page)
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Intrahepatic cholangiocarcinoma (iCCA) is a malignant disease of the biliary tree and the second most common primary liver cancer, accounts for 10% to 15% of hepatobiliary neoplasms(1), but its incidence and associated mortality rate have recently increased.(2) iCCA is hard to diagnose in its early stages, so by the time they are diagnosed, most patients have an advanced stage. Since chemotherapy or targeted therapy is limited, managing this cancer remains challenging.
Recent molecular analyses revealed several markers for poor prognosis including KRAS mutation and activation of oncogenic pathways (eg, HER2 and EGFR signaling).(3, 4) At the molecular level, iCCA has subgroups that are associated with different outcomes(3-6). However, relevance between molecular and clinic-pathologic features has not been fully known yet. Molecular characterization might be helpful for screening patients, predicting prognosis, and developing targeted therapies. However, applying molecular signatures in clinical settings is still not feasible because of the high cost for evaluating molecular characterization. If ... 전체 초록 보기
Recent molecular analyses revealed several markers for poor prognosis including KRAS mutation and activation of oncogenic pathways (eg, HER2 and EGFR signaling).(3, 4) At the molecular level, iCCA has subgroups that are associated with different outcomes(3-6). However, relevance between molecular and clinic-pathologic features has not been fully known yet. Molecular characterization might be helpful for screening patients, predicting prognosis, and developing targeted therapies. However, applying molecular signatures in clinical settings is still not feasible because of the high cost for evaluating molecular characterization. If ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-514-001919263