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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 200 - 200 (1page)
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이 논문의 연구 히스토리 (4)
2021
Integrative multi-omics profiling of resectable pancreatic cancer reveals clinically relevant molecular subtypes with precision strategies beyond the clinical staging system
Sung Hwan Lee
대한임상종양학회 학술대회지
2021.06
학술대회자료
Integrative analysis using multi-omics dataset reveal precision strategy based on cancer-specific molecular subtypes of bile duct cancer
Sung Hwan Lee
대한임상종양학회 학술대회지
2021.06
학술대회자료
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Background/Aims
Bile duct cancer is a heterogeneous tumor entity harboring distinct tumor biology and clinical phenotype according to their unique tumor microenvironment (TME), especially anatomic location in terms of intrahepatic, peri-hilar, and distal extrahepatic portion. Therefore, there is a clear unmet need for the precision strategy based on cancer-specific genomic features rather than previous molecular subtypes from bulk RNA sequencing.
Methods
Comprehensive analyses were performed using the dataset from the cancer dependency map (DepMap) project, including cancer-specific molecular characterization with multi-omics data, genome-wide loss-of-function screening with CRISPR-Cas9 system, and drug sensitivity with compound screening to uncover cancer-specific molecular subtypes showing clinical relevance. The cancer-specific molecular signatures were validated in independent translational cohorts (TCGA-CHOL; n=45, ICGC-BTC; n=181, GSE132305; n=220).
Results
Integrative profiling of transcriptome fro ... 전체 초록 보기
Bile duct cancer is a heterogeneous tumor entity harboring distinct tumor biology and clinical phenotype according to their unique tumor microenvironment (TME), especially anatomic location in terms of intrahepatic, peri-hilar, and distal extrahepatic portion. Therefore, there is a clear unmet need for the precision strategy based on cancer-specific genomic features rather than previous molecular subtypes from bulk RNA sequencing.
Methods
Comprehensive analyses were performed using the dataset from the cancer dependency map (DepMap) project, including cancer-specific molecular characterization with multi-omics data, genome-wide loss-of-function screening with CRISPR-Cas9 system, and drug sensitivity with compound screening to uncover cancer-specific molecular subtypes showing clinical relevance. The cancer-specific molecular signatures were validated in independent translational cohorts (TCGA-CHOL; n=45, ICGC-BTC; n=181, GSE132305; n=220).
Results
Integrative profiling of transcriptome fro ... 전체 초록 보기
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Precision strategy based on cancer-specific molecular subtypes of bile duct cancer from comprehensive analysis using multi-omics dataset
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Integrative multi-omics profiling of resectable pancreatic cancer reveals clinically relevant molecular subtypes with precision strategies beyond the clinical staging system
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UCI(KEPA) : I410-ECN-0101-2021-514-001919718