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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 164 - 164 (1page)
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Immunoediting is a dynamic process that changes host immune system from immunosurveillance to immune escape during tumor progression. Despite the recent advances in cancer immunotherapy targeting immune checkpoints, it remains unclear how tumor cells acquire an ability to shape a favorable immune landscape within tumor microenvironment. To identify immunoediting factors that promote tumor progression, we performed a comparative transcriptomic analysis using tumor tissues derived from syngeneic mice transplanted with B16 melanoma manipulated to accelerate the tumor growth, in comparison with mice received with control B16 cells. Among the tumor-intrinsic factors that were differentially expressed and putative immune-associated genes, delta-like noncanonical Notch ligand 1 (DLK1) was further validated its functional impact on tumor growth and immune microenvironment. Forced expression of DLK1 attenuated melanoma growth whereas knockdown of DLK1 enha ... 전체 초록 보기
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