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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 229 - 229 (1page)
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This study was conducted to establish the technology for bacterial reverse mutation test using 384-well microplates and liquid media instead of solid agar in order to evaluate the mutagenicity of test articles with limited amounts. The important advantage of this test method was considered that the usage of S9 fraction prepared from rat liver was smaller in comparison with the Ames test using solid agar. Five bacterial strains (Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2 uvrA) recommended in OECD 471 were used to evaluate 8 chemicals including 6 mutagens and 2 non-mutagens. All experiments were performed using Ames MPFTM Penta II kits (Xenometrix, Switzerland). Three independent laboratories participated in the int ... 전체 초록 보기
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