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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background and Purpose Liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma-glutamyl transpeptidase [GGT]) are glutamate-regulatory enzymes, and higher glutamate levels correlated with worse prognosis of patients with neurotrauma. However, less is known about the association between liver enzymes and incidence of stroke. We evaluated the association between serum levels of AST, ALT, and GGT and incidence of stroke in the Atherosclerosis Risk in Communities (ARIC) study cohort from 1990 to 1992 through December 31, 2016. Methods We included 12,588 ARIC participants without prevalent stroke and with data on liver enzymes ALT, AST, and GGT at baseline. We used multivariable Cox regression models to examine the associations between liver enzymes levels at baseline and stroke risk (overall, ischemic stroke, and intracerebral hemorrhage [ICH]) through December 31, 2016, adjusting for potential confounders. Results During a median follow-up time of 24.2 years, we observed 1,012 incident strokes (922 ischemic strokes and 90 ICH). In age, sex, and race-center adjusted models, the hazard ratios (HRs; 95% confidence intervals [CIs]) for the highest compared to lowest GGT quartile were 1.94 (95% CI, 1.64 to 2.30) for all incident stroke and 2.01 (95% CI, 1.68 to 2.41) for ischemic stroke, with the results supporting a dose-response association (P for linear trend <0.001). Levels of AST were associated with increased risk of ICH, but the association was significant only when comparing the third quartile with the lowest quartile (adjusted HR, 1.82; 95% CI, 1.06 to 3.13). Conclusions Elevated levels of GGT (within normal levels), independent of liver disease, are associated with higher risk of incident stroke overall and ischemic stroke, but not ICH.
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참고문헌 (4)
참고문헌 신청
Campos F / 2011 / High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke / J Cereb Blood Flow Metab 31:1387~1393
da Silva-Candal A / 2018 / Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke / Ann Neurol 84:260~273
Dufour DR / 2000 / Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests / Clin Chem 46:2027~2049
Lazo M / 2008 / Brief communication : clinical implications of short-term variability in liver function test results / Ann Intern Med 148:348~352
da Silva-Candal A / 2018 / Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke / Ann Neurol 84:260~273
Dufour DR / 2000 / Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests / Clin Chem 46:2027~2049
Lazo M / 2008 / Brief communication : clinical implications of short-term variability in liver function test results / Ann Intern Med 148:348~352
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