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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 373 - 378 (6page)
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Phosphorylation of the signaling component by protein kinase often leads to a kinase cascade or feedback loop. 3-Phosphoinositide- dependent kinase 1 (PDK1) signaling pathway diverges into various kinases including Akt and p70 S6 kinase (p70S6k). However, the PDK1 feedback mechanism remains elusive. Here, we demonstrated that UNC-51-like kinase (ULK1), an autophagy initiator kinase downstream of mechanistic target of rapamycin (mTOR), directly phosphorylated PDK1 on serine 389 at the linker region. Furthermore, our data showed that this phosphorylation affected the kinase activity of PDK1 toward downstream substrates. These results suggest a possible negative feedback loop between PDK1 and ULK1.
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참고문헌 (32)
참고문헌 신청
Rameh LE / 1999 / The role of phosphoinositide 3-kinase lipid products in cell function / J Biol Chem 274:8347~8350
Anderson KE / 1998 / Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B / Curr Biol 8:684~691
Alessi DR / 1997 / Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha / Curr Biol 7:261~269
Stephens L / 1998 / Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B / Science 279:710~714
Pullen N / 1998 / Phosphorylation and activation of p70s6k by PDK1 / Science 279:707~710
Anderson KE / 1998 / Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B / Curr Biol 8:684~691
Alessi DR / 1997 / Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha / Curr Biol 7:261~269
Stephens L / 1998 / Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B / Science 279:710~714
Pullen N / 1998 / Phosphorylation and activation of p70s6k by PDK1 / Science 279:707~710
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