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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 626 - 631 (6page)
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초록· 키워드
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Janus kinase 2 (JAK2), a non-receptor tyrosine kinase, is a criticalcomponent of cytokine and growth factor signaling pathwaysregulating hematopoietic cell proliferation. JAK2 mutations areassociated with multiple myeloproliferative neoplasms. Althoughphysiological and pathological functions of JAK2 in hematopoietictissues are well-known, such functions of JAK2 in thenervous system are not well studied yet. The present study demonstratedthat JAK2 could negatively regulate neuronal differentiationof mouse embryonic stem cells (ESCs). Depletion ofJAK2 stimulated neuronal differentiation of mouse ESCs andactivated glycogen synthase kinase 3?, Fyn, and cyclin-dependentkinase 5. Knockdown of JAK2 resulted in accumulation of GTPboundRac1, a Rho GTPase implicated in the regulation of cytoskeletaldynamics. These findings suggest that JAK2 might negativelyregulate neuronal differentiation by suppressing the GSK-3β/Fyn/CDK5 signaling pathway responsible for morphological maturation.
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참고문헌 (35)
참고문헌 신청
Leonard WJ / 1998 / Jaks and STATs : biological implications / Annu Rev Immunol 16:293~322
Behrmann I / 2004 / Janus kinase(Jak)subcellular localization revisited : the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak. receptor complex to be equivalent to a receptor tyrosine kinase / J Biol Chem 279:35486~35493
Ram PA / 1997 / Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase / J Biol Chem 272:17694~17702
Ihle JN / 2007 / Jak2 : normal function and role in hematopoietic disorders / Curr Opin Genet Dev 17:8~14
이해리 / 2019 / Highlighted STAT3 as a potential drug target for cancer therapy / BMB Reports 52(7):415~423
Behrmann I / 2004 / Janus kinase(Jak)subcellular localization revisited : the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak. receptor complex to be equivalent to a receptor tyrosine kinase / J Biol Chem 279:35486~35493
Ram PA / 1997 / Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase / J Biol Chem 272:17694~17702
Ihle JN / 2007 / Jak2 : normal function and role in hematopoietic disorders / Curr Opin Genet Dev 17:8~14
이해리 / 2019 / Highlighted STAT3 as a potential drug target for cancer therapy / BMB Reports 52(7):415~423
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