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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 686 - 693 (8page)
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Autophagy is an intracellular degradation system that breaks down damaged organelles or damaged proteins using intracellular lysosomes. Recent studies have also revealed that various forms of selective autophagy play specific physiological roles under different cellular conditions. Lipid droplets, which are mainly found in adipocytes and hepatocytes, are dynamic organelles that store triglycerides and are critical to health. Lipophagy is a type of selective autophagy that targets lipid droplets and is an essential mechanism for maintaining homeostasis of lipid droplets. However, while processes that regulate lipid droplets such as lipolysis and lipogenesis are relatively well known, the major factors that control lipophagy remain largely unknown. This review introduces the underlying mechanism by which lipophagy is induced and regulated, and the current findings on the major roles of lipophagy in physiological and pathological status. These studies will provide basic insights into the function of lipophagy and may be useful for the development of new therapies for lipophagy dysfunction-related diseases.
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참고문헌 (89)
참고문헌 신청
Baerga, R. / 2009 / Targeted deletion of autophagy-related 5(atg5)impairs adipogenesis in a cellular model and in mice / Autophagy 5:1118~1130
Barbato, D. L. / 2013 / FoxO1 controls lysosomal acid lipase in adipocytes : implication of lipophagy during nutrient restriction and metformin treatment / Cell Death Dis 4:e861
Bruschi, F. V. / 2017 / The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells / Hepatology 65:1875~1890
Byun, S. / 2020 / Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase / Nat. Commun 11:807
Cai, J. / 2018 / Autophagy ablation in adipocytes induces insulin resistance and reveals roles for lipid peroxide and Nrf2 signaling in adipose-liver crosstalk / Cell Rep 25:1708~1717
Barbato, D. L. / 2013 / FoxO1 controls lysosomal acid lipase in adipocytes : implication of lipophagy during nutrient restriction and metformin treatment / Cell Death Dis 4:e861
Bruschi, F. V. / 2017 / The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells / Hepatology 65:1875~1890
Byun, S. / 2020 / Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase / Nat. Commun 11:807
Cai, J. / 2018 / Autophagy ablation in adipocytes induces insulin resistance and reveals roles for lipid peroxide and Nrf2 signaling in adipose-liver crosstalk / Cell Rep 25:1708~1717
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