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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 55 - 64 (10page)
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Autophagy is an intracellular degradation path-way for large protein aggregates and damaged organelles. Recent studies have indicated that autophagy targets cargoes through a selective degradation pathway called selective autophagy. Peroxisomes are dynamic organelles that are crucial for health and development. Pexophagy is selective autophagy that targets peroxisomes and is essential for the maintenance of homeostasis of peroxisomes, which is necessary in the prevention of various peroxisome-related disorders. However, the mechanisms by which pexophagy is regulated and the key players that induce and modulate pexophagy are largely un-known. In this review, we focus on our current understanding of how pexophagy is induced and regulated, and the selective adaptors involved in mediating pexophagy. Furthermore, we discuss current findings on the roles of pexophagy in physiological and pathological responses, which provide insight into the clinical relevance of pexophagy regulation. Understanding how pexophagy interacts with various biological func-tions will provide fundamental insights into the function of pexophagy and facilitate the development of novel therapeutics against peroxisomal dysfunction-related diseases.
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참고문헌 (100)
참고문헌 신청
Al-Dirbashi, O.Y. / 2009 / Zellweger syndrome caused by PEX13 deficiency: report of two novel mutations / Am. J. Med. Genet. A 149A:1219~1223
Anding, A.L. / 2017 / Cleaning House: Selective Autophagy of Organelles / Dev. Cell 41:10~22
Baroy, T. / 2015 / A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform / Hum. Mol. Genet. 24:5845~5854
Bjorkoy, G. / 2005 / p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death / J. Cell Biol. 171:603~614
Bonekamp,N.A. / 2009 / Reactive oxygen species and peroxisomes: struggling for balance / Biofactors 35:346~355
Anding, A.L. / 2017 / Cleaning House: Selective Autophagy of Organelles / Dev. Cell 41:10~22
Baroy, T. / 2015 / A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform / Hum. Mol. Genet. 24:5845~5854
Bjorkoy, G. / 2005 / p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death / J. Cell Biol. 171:603~614
Bonekamp,N.A. / 2009 / Reactive oxygen species and peroxisomes: struggling for balance / Biofactors 35:346~355
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