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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,023 - 1,034 (12page)
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Complement fragment iC3b serves as a major opsonin for facilitating phagocytosis via its interaction with complement receptors CR3 and CR4, also known by their leukocyte integrin family names, αMβ2 and αXβ2, respectively. Although there is general agreement that iC3b binds to the αM and αX I-domains of the respective β2-integrins, much less is known regarding the regions of iC3b contributing to the αX I-domain binding. In this study, using recombinant αX I-domain, as well as recombinant fragments of iC3b as candidate binding partners, we have identified two distinct binding moieties of iC3b for the αX I-domain. They are the C3 convertase-generated N-terminal segment of the C3b α’- chain (α’NT) and the factor I cleavage-generated N-terminal segment in the CUBf region of α-chain. Additionally, we have found that the CUBf segment is a novel binding moiety of iC3b for the αM I-domain. The CUBf segment shows about a 2-fold higher binding activity than the α’NT for αX I-domain. We also have shown the involvement of crucial acidic residues on the iC3b side of the interface and basic residues on the I-domain side.
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참고문헌 (31)
참고문헌 신청
Arnaout, M. A. / 2005 / Integrin structure, allostery, and bidirectional signaling / Annu. Rev. Cell Dev. Biol 21:381~410
Bajic, G. / 2013 / Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3 / Proc. Natl. Acad. Sci. U. S. A 110:16426~16431
Becherer, J. D. / 1992 / Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B / Biochemistry 31:1787~1794
Carroll, M. C / 2004 / The complement system in regulation of adaptive immunity / Nat. Immunol 5:981~986
Jeongsuk Choi / 2010 / Characterization of the Residues of αX I-Domain and ICAM-1 Mediating Their Interactions / Molecules and Cells 30(3):227~234
Bajic, G. / 2013 / Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3 / Proc. Natl. Acad. Sci. U. S. A 110:16426~16431
Becherer, J. D. / 1992 / Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B / Biochemistry 31:1787~1794
Carroll, M. C / 2004 / The complement system in regulation of adaptive immunity / Nat. Immunol 5:981~986
Jeongsuk Choi / 2010 / Characterization of the Residues of αX I-Domain and ICAM-1 Mediating Their Interactions / Molecules and Cells 30(3):227~234
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