지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.5
- 수록면
- 355 - 362 (8page)
이용수
초록· 키워드
오류제보하기
The 2 integrins are cell surface transmembrane proteins regulating leukocyte functions, such as adhesion and migration. Two members of 2 integrin, M 2 and X 2, share the leukocyte distribution profile and integrin X 2 is involved in antigen presentation in dendritic cells and transendothelial migration of monocytes and macrophages to atherosclerotic lesions. Receptor for advanced glycation end products (RAGE), a member of cell adhesion molecules, plays an important role in chronic inflammation and atherosclerosis. Although RAGE and X 2 play an important role in inflammatory response and the pathogenesis of atherosclerosis, the nature of their interaction and structure involved in the binding remain poorly defined. In this study, using I-domain as a ligand binding motif of X 2, we characterize the binding nature and the interacting moieties of X I-domain and RAGE. Their binding requires divalent cations (Mg2+ and Mn2+) and shows an affinity on the sub-micro molar level: the dissociation constant of X I-domains binding to RAGE being 0.49 μM. Furthermore, the X I-domains recognize the V-domain, but not the C1 and C2-domains of RAGE. The acidic amino acid substitutions on the ligand binding site of X I-domain significantly reduce the I-domain binding activity to soluble RAGE and the alanine substitutions of basic amino acids on the flat surface of the V-domain prevent the V-domain binding to X I-domain. In conclusion, the main mechanism of X I-domain binding to RAGE is a charge interaction, in which the acidic moieties of X I-domains, including E244, and D249, recognize the basic residues on the RAGE V-domain encompassing K39, K43, K44, R104, and K107.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Arnaout, M. A. / 2002 / Integrin structure: new twists and turns in dynamic cell adhesion / Immunol. Rev 186:125~140
Baker, N. A. / 2001 / Electrostatics of nanosystems: application to microtubules and the ribosome / Proc. Natl. Acad. Sci. USA 98:10037~10041
Chavakis, T. / 2003 / The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment / J. Exp. Med 198:1507~1515
Choi, J. / 2005 / Characterization of X Idomain binding to Thy-1 / Biochem. Biophy. Res. Comm 331:557~561
Jeongsuk Choi / 2010 / Characterization of the Residues of αX I-Domain and ICAM-1 Mediating Their Interactions / Molecules and Cells 30(3):227~234
Baker, N. A. / 2001 / Electrostatics of nanosystems: application to microtubules and the ribosome / Proc. Natl. Acad. Sci. USA 98:10037~10041
Chavakis, T. / 2003 / The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment / J. Exp. Med 198:1507~1515
Choi, J. / 2005 / Characterization of X Idomain binding to Thy-1 / Biochem. Biophy. Res. Comm 331:557~561
Jeongsuk Choi / 2010 / Characterization of the Residues of αX I-Domain and ICAM-1 Mediating Their Interactions / Molecules and Cells 30(3):227~234
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
ON SOME UNBOUNDED DOMAINS FOR A MAXIMUM PRINCIPLE
순수 및 응용수학
2016 .01
-
Purification, crystallization and X-ray diffraction of heparan sulfate bounded human RAGE
Biodesign
2017 .09
-
Moieties of Complement iC3b Recognized by the I-domain of Integrin αXβ2
Molecules and Cells
2020 .01
-
KAPLANSKY-TYPE THEOREMS IN GRADED INTEGRAL DOMAINS
대한수학회보
2015 .01
-
Effects of Co-Expression of Liver X Receptor β-Ligand Binding Domain with its Partner, Retinoid X Receptor α-Ligand Binding Domain, on their Solubility and Biological Activity in Escherichia coli
Journal of Microbiology and Biotechnology
2015 .01
-
A HALF-CENTERED STAR-OPERATION ON AN INTEGRAL DOMAIN
대한수학회지
2017 .01
-
A new characterization of Pr\"ufer $v$-multiplication domains
한국수학논문집
2015 .01
-
Trace Properties and Integral Domains, III
대한수학회보
2022 .03
-
An Ensemble Approach to Domain Adaptation in Sentiment Analysis
Journal of The Korean Data Analysis Society
2019 .01
-
Some remarks on $S$-valuation domains
대한수학회논문집
2024 .01
-
Pullbacks of $\mathcal{C}$-hereditary domains
대한수학회보
2018 .01
-
Domains with flat boundary pieces
대한수학회보
2016 .01
-
Research trends on the aspect of professional development of mathematics teachers
East Asian Mathematical Journal
2016 .01
-
GRADED INTEGRAL DOMAINS AND PRUFER-LIKE DOMAINS
대한수학회지
2017 .01
-
Determination of magnetic domain-wall types via observing Dzyaloshinskii-Moriya interaction-induced domain expansion patterns
한국자기학회 학술연구발표회 논문개요집
2015 .11
-
Logic Devices based on Domain Wall Motion in Chiral-Coupled Nanomagnets
한국자기학회 학술연구발표회 논문개요집
2019 .11
-
Sequencing Analysis of Ligand Binding Domain of Aryl Hydrocarbon Receptor which is a Dioxin Sensitive Gene in the Ornamental Birds
한국조류학회지
2015 .12
-
Generalized Equation for Magnetic Domain Wall Chirality with Consideration of Domain Wall tilting
한국자기학회 학술연구발표회 논문개요집
2020 .11
-
Domain of influence of Local Volatility Function on the Solutions of the General Black-Scholes Equation
순수 및 응용수학
2020 .01
-
Stochastic Domain Wall Motion and Thermal Field Characterization
한국자기학회 학술연구발표회 논문개요집
2019 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0