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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제8호
- 발행연도
- 2020.1
- 수록면
- 1,222 - 1,226 (5page)
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초록· 키워드
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Lactobacillus reuteri NK33 (NK33) and Bifidobacterium adolescentis NK98 (NK98) alleviate immobilization stress-induced depression. To understand the gut microbiota-mediated mechanisms of NK33 and NK98 against depression, we examined their effects on Escherichia coli K1 (K1)-induced depression and gut dysbiosis in mice. NK33, NK98, and their mixtures (1:1, 4:1, and 9:1) mitigated K1-induced depression and colitis. NK33 and NK98 additively or synergistically increased BDNF+/NeuN+ cell population and suppressed NF-κB action in the hippocampus. They alleviated gut dysbiosis by reducing the Proteobacteria population and increasing the Clostridia population. These results suggest that NK33 and NK98 may alleviate depression and colitis by ameliorating gut dysbiosis.
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참고문헌 (23)
참고문헌 신청
El Aidy S / 2014 / Immune modulation of the brain-gut-microbe axis / Front. Microbiol 5:146
Shadi S Yarandi / 2016 / Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases / Journal of Neurogastroenterology and Motility (JNM) 22(2):201~212
Jang SE / 2018 / Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice / Mucosal Immunol 11:369~379
Jang HM / 2018 / Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice / Mucosal Immunol 11:1386~1397
Kim JK / 2020 / Interplay between human gut bacteria Escherichia coli and Lactobacillus mucosae in the occurrence of neuropsychiatric disorders in mice / Front. Immunol 11:273
Shadi S Yarandi / 2016 / Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases / Journal of Neurogastroenterology and Motility (JNM) 22(2):201~212
Jang SE / 2018 / Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice / Mucosal Immunol 11:369~379
Jang HM / 2018 / Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice / Mucosal Immunol 11:1386~1397
Kim JK / 2020 / Interplay between human gut bacteria Escherichia coli and Lactobacillus mucosae in the occurrence of neuropsychiatric disorders in mice / Front. Immunol 11:273
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