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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제9호
- 발행연도
- 2020.1
- 수록면
- 1,305 - 1,309 (5page)
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초록· 키워드
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Insects possess biological defense systems that can effectively combat the invasion of external microorganisms and viruses, thereby supporting their survival in diverse environments. Antimicrobial peptides (AMPs) represent a fast-acting weapon against invading pathogens, including various bacterial or fungal strains. A 37-residue antimicrobial peptide, papiliocin, derived from the swallowtail butterfly Papilio xuthus larvae, showed significant antimicrobial activities against several human pathogenic bacterial and fungal strains. Jelleines, isolated as novel antibacterial peptides from the Royal Jelly (RJ) of bees, exhibit broad-spectrum protection against microbial infections. In this study, we developed a novel antimicrobial peptide, PAJE (RWKIFKKPFKISIHL-NH2), which is a hybrid peptide prepared by combining 1?7 amino acid residues (RWKIFKK-NH2) of papiliocin and 1?8 amino acid residues (PFKISIHL-NH2) of Jelleine-1 to alter length, charge distribution, net charge, volume, amphipaticity, and improve bacterial membrane interactions. This novel peptide exhibited increased hydrophobicity and net positive charge for binding effectively to the negatively charged membrane. PAJE demonstrated antimicrobial activity against both gram-negative and gram-positive bacteria, with very low toxicity to eukaryotic cells and an inexpensive process of synthesis. Collectively, these findings suggest that this novel peptide possesses great potential as an antimicrobial agent.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Fontana R / 2004 / Jelleines : a family of antimicrobial peptides from the Royal Jelly of honybees(Apis mellifera) / Peptides 2:919~928
Hoffman JA / 1999 / Phylogenetic perspectives in innate immunity / Science 284:1313~1318
Hwang B / 2011 / Induction of yeast apoptosis by an antimicrobial peptide, Papiliocin / Biochem. Biophys. Res. Commun 408:89~93
이동건 / 2010 / Isolation and Characterization of Psacotheasin, a Novel Knottin-Type Antimicrobial Peptide, from Psacothea hilaris / Journal of Microbiology and Biotechnology 20(4):708~711
Seong Ryul Kim / 2010 / Characterization and cDNA Cloning of a Cecropin-Like Antimicrobial Peptide, Papiliocin, from the Swallowtail Butterfly, Papilio xuthus / Molecules and Cells 29(4):419~423
Hoffman JA / 1999 / Phylogenetic perspectives in innate immunity / Science 284:1313~1318
Hwang B / 2011 / Induction of yeast apoptosis by an antimicrobial peptide, Papiliocin / Biochem. Biophys. Res. Commun 408:89~93
이동건 / 2010 / Isolation and Characterization of Psacotheasin, a Novel Knottin-Type Antimicrobial Peptide, from Psacothea hilaris / Journal of Microbiology and Biotechnology 20(4):708~711
Seong Ryul Kim / 2010 / Characterization and cDNA Cloning of a Cecropin-Like Antimicrobial Peptide, Papiliocin, from the Swallowtail Butterfly, Papilio xuthus / Molecules and Cells 29(4):419~423
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