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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 273 - 278 (6page)
- DOI
- 10.14348/molcells.2015.2320
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초록· 키워드
오류제보하기
The induction of angiogenesis is a crucial step in tumor progression, and therefore, efficient inhibition of angiogenesis is considered a powerful strategy for the treatment of cancer. In the present study, we report that the lipophilic antimicrobial peptides from EML-CAP3, a new endophytic bacterial strain isolated from red pepper leaf (Capsicum annuum L.), exhibit potent antiangiogenic activity both in vitro and in vivo. The newly obtained antimicrobial peptides effectively inhibited the proliferation of human umbilical vein endothelial cells at subtoxic doses. Furthermore, the peptides suppressed the in vitro characteristics of angiogenesis such as endothelial cell invasion and tube formation stimulated by vascular endothelial growth factor, as well as neovascularization of the chorioallantoic membrane of growing chick embryos in vivo without showing cytotoxicity. Notably, the angiostatic peptides blocked tumor cell-induced angiogenesis by suppressing the expression levels of hypoxia-inducible factor-1α and its target gene, vascular endothelial growth factor (VEGF). To our knowledge, our findings demonstrate for the first time that the antimicrobial peptides from EML-CAP3 possess antiangiogenic potential and may thus be used for the treatment of hypervascularized tumors.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Andre, T. / 1998 / Tumoral angiogenesis : physiopathology, prognostic value and therapeutic perspectives / Rev. Med. Interne 19:904~913
Battegay, E. J. / 1995 / Angiogenesis : mechanistic insights, neovascular diseases, and therapeutic prospects / J. Mol. Med 73:333~346
Brogden, K. A. / 2005 / Antimicrobial peptides : pore formers or metabolic inhibitors in bacteria? / Nat. Rev. Microbiol 3:238~250
Bussolino, F. / 1997 / Molecular mechanisms of blood vessel formation / Trends Biochem. Sci 22:251~256
Curr. Pharm. Des / 2006 / VEGF inhibitors in cancer therapy / Des 12:387~394
Battegay, E. J. / 1995 / Angiogenesis : mechanistic insights, neovascular diseases, and therapeutic prospects / J. Mol. Med 73:333~346
Brogden, K. A. / 2005 / Antimicrobial peptides : pore formers or metabolic inhibitors in bacteria? / Nat. Rev. Microbiol 3:238~250
Bussolino, F. / 1997 / Molecular mechanisms of blood vessel formation / Trends Biochem. Sci 22:251~256
Curr. Pharm. Des / 2006 / VEGF inhibitors in cancer therapy / Des 12:387~394
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