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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 225 - 231 (7page)
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초록· 키워드
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Glial cells, including astrocytes and microglia, interact closely with neurons and modulate pain transmission,particularly under pathological conditions. In this study, we examined the excitability of substantia gelatinosa (SG)neurons of the spinal dorsal horn using a patch clamp recording to investigate the roles of microglial activation inthe nociceptive processes of rats. We used xanthine/xanthine oxidase (X/XO), a generator of superoxide anion (O2??),to induce a pathological pain condition. X/XO treatment induced an inward current and membrane depolarization. The inward current was significantly inhibited by minocycline, a microglial inhibitor, and fluorocitrate, an astrocyteinhibitor. To examine whether toll-like receptor 4 (TLR4) in microglia was involved in the inward current, we usedlipopolysaccharide (LPS), a highly specific TLR4 agonist. The LPS induced inward current, which was decreasedby pretreatment with Tak-242, a TLR4-specific inhibitor, and phenyl N-t-butylnitrone, a reactive oxygen speciesscavenger. The X/XO-induced inward current was also inhibited by pretreatment with Tak-242. These results indicatethat the X/XO-induced inward current of SG neurons occurs through activation of TLR4 in microglial cells, suggestingthat neuroglial cells modulate the nociceptive process through central sensitization.
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참고문헌 (39)
참고문헌 신청
M. Yoshimura / 1989 / Membrane properties of rat substantia gelatinosa neurons in vitro / Journal of Neurophysiology 62(1):109~118
Wiebke Kallenborn-Gerhardt / 2013 / NOXious signaling in pain processing / Pharmacology & Therapeutics 137(3):309~317
Erica S. Schwartz / 2008 / Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice / Pain 138(3):514~524
Kim HY / 2015 / Reactive oxygen species donors increase the responsiveness of dorsal horn neurons and induce mechanical hyperalgesia in rats / Neural Plast 2015:293423
박아름 / 2018 / Pre- and Postsynaptic Actions of Reactive Oxygen Species and Nitrogen Species in Spinal Substantia Gelatinosa Neurons / International Journal of Oral Biology 43(4):209~216
Wiebke Kallenborn-Gerhardt / 2013 / NOXious signaling in pain processing / Pharmacology & Therapeutics 137(3):309~317
Erica S. Schwartz / 2008 / Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice / Pain 138(3):514~524
Kim HY / 2015 / Reactive oxygen species donors increase the responsiveness of dorsal horn neurons and induce mechanical hyperalgesia in rats / Neural Plast 2015:293423
박아름 / 2018 / Pre- and Postsynaptic Actions of Reactive Oxygen Species and Nitrogen Species in Spinal Substantia Gelatinosa Neurons / International Journal of Oral Biology 43(4):209~216
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