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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 55 - 61 (7page)
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초록· 키워드
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Recent studies indicate that mitochondria are an important source of reactive oxygen species (ROS) in the spinal dorsal horn. In our previous study, application of malate, a mitochondrial electron transport complex I substrate, induced a membrane depolarization, which was inhibited by pretreatment with ROS scavengers. In the present study, we used patch clamp recording in the substantia geletinosa (SG) neurons of spinal slices, to investigate the cellular mechanism of mitochondrial ROS on neuronal excitability. DNQX (an AMPA receptor antagonist) and AP5 (an NMDA receptor antagonist) decreased the malate-induced depolarization. In an external calcium free solution and addition of tetrodotoxin (TTX) for blockade of synaptic transmission, the malateinduced depolarization remained unchanged. In the presence of DNQX, AP5 and AP3 (a groupⅠ metabotropic glutamate receptor (mGluR) antagonist), glutamate depolarized the membrane potential, which was suppressed by PBN.
However, oligomycin (a mitochondrial ATP synthase inhibitor) or PPADS (a P2 receptor inhibitor) did not affect the substrates-induced depolarization. These results suggest that mitochondrial substrate-induced ROS in SG neuron directly acts on the postsynaptic neuron, therefore increasing the ion influx via glutamate receptors.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alexander Panov / 2009 / The Neuromediator Glutamate, through Specific Substrate Interactions, Enhances Mitochondrial ATP Production and Reactive Oxygen Species Generation i
Ana Navarro / 2004 / Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging / Am J Physiol Regul Integr Comp Physiol 287 (5) : R124
Cai J / 1998 / Mitochondrial generation triggered by cytochrome c loss / Biol Chem 273 (19) : 11401 ~ 11404
Chance B / 1979 / Hydroperoxide metabolism in mammalian organs / Physiol Rev 59 (3) : 527 ~ 605
Chen Q / 2003 / Production of reactive oxygen species by mitochondria:central role of complex III / J Biol Chem 278 (38) : 36027 ~ 36031
Ana Navarro / 2004 / Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging / Am J Physiol Regul Integr Comp Physiol 287 (5) : R124
Cai J / 1998 / Mitochondrial generation triggered by cytochrome c loss / Biol Chem 273 (19) : 11401 ~ 11404
Chance B / 1979 / Hydroperoxide metabolism in mammalian organs / Physiol Rev 59 (3) : 527 ~ 605
Chen Q / 2003 / Production of reactive oxygen species by mitochondria:central role of complex III / J Biol Chem 278 (38) : 36027 ~ 36031
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