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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제5호
- 발행연도
- 2020.1
- 수록면
- 351 - 360 (10page)
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초록· 키워드
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Recent advances in immuno-oncology have increased understanding of the tumor immune microenvironment (TIME), and clinical trials for immune checkpoint inhibitor treatment have shown remission and/or durable response in certain proportions of patients stratified by predictive biomarkers. The TIME in colorectal cancer (CRC) was initially evaluated several decades ago. The prognostic value of the immune response to tumors, including tumor-infiltrating lymphocytes, peritumoral lymphoid reaction, and Crohn’s-like lymphoid reaction, has been well demonstrated. In this review, we describe the chronology of TIME research and review the up-to-date high-dimensional TIME landscape of CRC. We also summarize the clinical relevance of several biomarkers associated with immunotherapy in CRC, such as microsatellite instability, tumor mutational burden, POLE/POLD mutation, consensus molecular subtype, and programmed death-ligand 1 expression.
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참고문헌 (16)
참고문헌 신청
Wang C / 2018 / Immune profiling of microsatellite instability-high and polymerase epsilon(POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy / J Gastrointest Oncol 9:404~415
Robyn Silberman / 2019 / Complete and prolonged response to immune checkpoint blockade in POLE-mutated colorectal cancer / JCO Precision Oncology (3):1~5
De Sousa EM / 2013 / Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions / Nat Med 19:614~618
Sadanandam A / 2013 / A colorectal cancer classification system that associates cellular phenotype and responses to therapy / Nat Med 19:619~625
Marisa L / 2013 / Gene expression classification of colon cancer into molecular subtypes : characterization, validation, and prognostic value / PLoS Med 10:e1001453
Robyn Silberman / 2019 / Complete and prolonged response to immune checkpoint blockade in POLE-mutated colorectal cancer / JCO Precision Oncology (3):1~5
De Sousa EM / 2013 / Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions / Nat Med 19:614~618
Sadanandam A / 2013 / A colorectal cancer classification system that associates cellular phenotype and responses to therapy / Nat Med 19:619~625
Marisa L / 2013 / Gene expression classification of colon cancer into molecular subtypes : characterization, validation, and prognostic value / PLoS Med 10:e1001453
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