지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제6호
- 발행연도
- 2020.1
- 수록면
- 504 - 507 (4page)
이용수
초록· 키워드
오류제보하기
Monoclonal gammopathy of renal significance is defined as any B cell or plasma cell clonal lymphoproliferation which neither causes tumor complications nor meets any current hematological criteria for specific therapy, with one or more kidney lesions related to the produced monoclonal immunoglobulin, such as amyloidosis. A 50-year-old male presented with heavy proteinuria and blood tests showing IgA and Lambda paraproteinemia. Light microscopy showed mesangial eosinophilic ground substance extending into the capillary loops, and positive staining within the glomeruli and vessel walls for amyloid P immunohistochemistry was also noted. Immunofluorescence showed positive staining for IgA and Lambda in the mesangia and capillary loops. Electron microscopy exhibited organized fibrils measuring 4?5 nm in diameter in the mesangia, glomerular basement membranes and vessel walls. We interpreted the overall findings as atypical renal amyloidosis with IgA and Lambda deposition on immunofluorescence. Further amyloid typing using laser microdissection-liquid chromatography and mass spectrometry will be useful.
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Westermark P / 2007 / A primer of amyloid nomenclature / Amyloid 14:179~183
Holanda DG / 2011 / Atypical presentation of atypical amyloid / Nephrol Dial Transplant 26:373~376
Leung N / 2019 / The evaluation of monoclonal gammopathy of renal significance : a consensus report of the International Kidney and Monoclonal Gammopathy Research Group / Nat Rev Nephrol 15:45~59
Leung N / 2018 / Dysproteinemias and glomerular disease / Clin J Am Soc Nephrol 13:128~139
Suhr OB / 2017 / One mutation, two distinct disease variants : unravelling the impact of transthyretin amyloid fibril composition / J Intern Med 281:337~347
Holanda DG / 2011 / Atypical presentation of atypical amyloid / Nephrol Dial Transplant 26:373~376
Leung N / 2019 / The evaluation of monoclonal gammopathy of renal significance : a consensus report of the International Kidney and Monoclonal Gammopathy Research Group / Nat Rev Nephrol 15:45~59
Leung N / 2018 / Dysproteinemias and glomerular disease / Clin J Am Soc Nephrol 13:128~139
Suhr OB / 2017 / One mutation, two distinct disease variants : unravelling the impact of transthyretin amyloid fibril composition / J Intern Med 281:337~347
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