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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 107 - 113 (7page)
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ObjectiveConsidering the high prevalence of leiomyoma and endometrial polyps, investigating the contributing factors anddetermining the pathophysiology of these lesions are essential. Target therapy is now an acceptable method forthe treatment of some diseases. We aimed to determine the expression of transforming growth factor (TGF)-β1 inendometrial polyps and leiomyomas to discover a drug-based method to overcome surgical treatments. MethodsIn this cross-sectional study, 55 patients with leiomyoma and 55 patients with polyps were included. Preparedslides from leiomyoma and adjacent myometrium or polyp lesions and adjacent endometrium were obtained andinvestigated for TGF-β1. Then, data were collected and analyzed using SPSS version 22. ResultsThe mean age of participants was 40.6±5.8 years. Based on their reports, 88.2% (n=97) of patients in the studypopulation had abnormal uterine bleeding with similar distributions among both groups. In contrast, 63.5% ofthe leiomyoma group did not express TGF-β1. However, in normal myometrium, 23.6% had the highest degree ofTGF-β1 expression. Polyp tissue did not show staining for TGF-β1 in any patients. Additionally, 89.1% of non-polypoidendometrium did not express TGF-β1. Normal tissue had a significantly greater amount of TGF-β1 compared toleiomyoma and endometrial polyps. ConclusionTGF-β1 is expressed more prominently in normal myometrium with mostly high-intensity features compared toleiomyoma. Additionally, polyps showed no staining for TGF-β1, while normal endometrium showed a low-densitystaining pattern.
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참고문헌 (26)
참고문헌 신청
Lewis TD / 2018 / A comprehensive review of the pharmacologic management of uterine leiomyoma / BioMed Res Int 2018:2414609
Soliman AM / 2017 / Impact of uterine fibroid symptoms on health-related quality of life of US women : evidence from a cross-sectional survey / Curr Med Res Opin 33:1971~1978
Parker WH / 2007 / Etiology, symptomatology, and diagnosis of uterine myomas / Fertil Steril 87:725~736
Arici A / 2000 / Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation / Fertil Steril 73:1006~1011
Lee BS / 2001 / Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-β 3(TGF β 3)and altered responses to the antiproliferative effects of TGF β / J Clin Endocrinol Metab 86:913~920
Soliman AM / 2017 / Impact of uterine fibroid symptoms on health-related quality of life of US women : evidence from a cross-sectional survey / Curr Med Res Opin 33:1971~1978
Parker WH / 2007 / Etiology, symptomatology, and diagnosis of uterine myomas / Fertil Steril 87:725~736
Arici A / 2000 / Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation / Fertil Steril 73:1006~1011
Lee BS / 2001 / Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-β 3(TGF β 3)and altered responses to the antiproliferative effects of TGF β / J Clin Endocrinol Metab 86:913~920
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